{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,22]],"date-time":"2026-04-22T03:11:43Z","timestamp":1776827503785,"version":"3.51.2"},"reference-count":34,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,5,23]],"date-time":"2019-05-23T00:00:00Z","timestamp":1558569600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To assess the cytological diagnosis and follow\u2010up of patients suffering from vitreoretinal lymphoma (<jats:styled-content style=\"fixed-case\">VRL<\/jats:styled-content>) diagnosed in our institution.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Results<\/jats:title><jats:p>From January 2010 to June 2017, we collected 15 patients with <jats:styled-content style=\"fixed-case\">VRL<\/jats:styled-content>. Twelve patients had diffuse large B\u2010cell lymphoma (<jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>); of these, 11 had primary central nervous system (<jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content>) <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>, one had ocular localisation of follicular lymphoma, one had extranodal <jats:styled-content style=\"fixed-case\">NK<\/jats:styled-content>\/T\u2010cell nasal type lymphoma and one had chronic lymphocytic leukaemia. The results of the cytological examination (cell morphology and immunocytochemistry) of the vitreous fluid were available for 9\/15 <jats:styled-content style=\"fixed-case\">VRL<\/jats:styled-content>. The interleukin\u201010\/\u20106 ratio was &gt;1 in eight of 12 <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content>. Molecular testing was useful in 6\/15 cases (clonality evaluation or <jats:italic><jats:styled-content style=\"fixed-case\">MYD<\/jats:styled-content>88 L265P<\/jats:italic> mutation testing). Eight out of 11 primary <jats:styled-content style=\"fixed-case\">CNS DLBCL<\/jats:styled-content> patients had <jats:styled-content style=\"fixed-case\">CNS<\/jats:styled-content> involvement, with 22\u2010month progression\u2010free survival. In our series, only two out of 11 <jats:styled-content style=\"fixed-case\">CNS DLBCL<\/jats:styled-content> patients died of disease after 2 and 5\u00a0years, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The short delay to assert the diagnosis of <jats:styled-content style=\"fixed-case\">VRL<\/jats:styled-content> could explain the quite good prognosis in our series, which highlights the need to consider a diagnosis of <jats:styled-content style=\"fixed-case\">DLBCL<\/jats:styled-content> as first step. The cytological features, as a reliable way to identify VRL, must always guide the choice of techniques for further investigations given the small amount of vitreous fluid available for analysis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12711","type":"journal-article","created":{"date-parts":[[2019,4,29]],"date-time":"2019-04-29T13:17:46Z","timestamp":1556543866000},"page":"385-392","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Cytological diagnosis of vitreoretinal lymphomas: A case series"],"prefix":"10.1111","volume":"30","author":[{"given":"Jean\u2010Claude","family":"Quintyn","sequence":"first","affiliation":[{"name":"Ophthalmology Department CHU Purpan University Hospital Toulouse France"},{"name":"Ophthalmology Department CHU Caen France"},{"name":"Normandie University UNICAEN CHU de Caen Normandie Unit\u00e9 de recherche UMR\u2010S 1075 INSERM\u2010UNICAEN Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priscille","family":"Olle","sequence":"additional","affiliation":[{"name":"Ophthalmology Department CHU Purpan University Hospital Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Monique","family":"Courtade\u2010Saidi","sequence":"additional","affiliation":[{"name":"Pathology and Cytology Department CHU Institut Universitaire du Cancer\u2010Oncopole University Hospital Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camille","family":"Laurent","sequence":"additional","affiliation":[{"name":"Pathology and Cytology Department CHU Institut Universitaire du Cancer\u2010Oncopole University Hospital Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucie","family":"Ob\u00e9ric","sequence":"additional","affiliation":[{"name":"Hematology Department CHU Institut Universitaire du Cancer\u2010Oncopole University Hospital Toulouse France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9025-6768","authenticated-orcid":false,"given":"Marie\u2010Laure","family":"Quintyn\u2010Ranty","sequence":"additional","affiliation":[{"name":"Pathology and Cytology Department CHU Institut Universitaire du Cancer\u2010Oncopole University Hospital Toulouse France"},{"name":"Pathology Department CHU Caen France"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2019,5,23]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1634\/theoncologist.2011-0210"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31820a6743"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1080\/09273940903168696"},{"key":"e_1_2_8_5_1","unstructured":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues Lyon France: IARC WHO Classification of Tumours 2017."},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/now033"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-01-643569"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.12621"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2012.246"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000000996"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.22608\/APO.2017150"},{"key":"e_1_2_8_12_1","unstructured":"Th\u00e9saurus de chimioth\u00e9rapie Neurologie (Oncomip).2013.http:\/\/oncomip.org\/fr\/espace-professionnel\/referentiels\/neurologie.html. 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