{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,23]],"date-time":"2026-07-23T10:59:43Z","timestamp":1784804383851,"version":"3.55.0"},"reference-count":21,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2019,6,19]],"date-time":"2019-06-19T00:00:00Z","timestamp":1560902400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2019,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To retrospectively analyse the incidence of high\u2010grade squamous intraepithelial lesions (<jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>s) and squamous cell carcinoma (<jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content>) in women of different ages with high\u2010risk (<jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>) human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) but with normal cytology test results stratified by age and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In total, 1858 women with <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infection but with a normal smear who received a colposcopy and biopsy between 2015 and 2016 at our institution were included. The pathological results were retrospectively analysed after stratifying by age and <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> genotype.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among the 1858 cases, the <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>% in women aged 21\u201029\u00a0years (10.54%) was significantly different from that in women aged 40\u201049\u00a0years (19.85%; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05), whereas there was no significant difference in the <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>% among women aged 21\u201029\u00a0years and those in the other age groups (<jats:italic>P<\/jats:italic>\u00a0&gt;\u00a00.05). In total, 295 cases had single <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16 infection. The <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>% in patients with <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16\/18 infection was &gt;15%, and the 40\u201049\u2010year age group had the highest percentage at 48.48%. For other <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infections, the <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content> and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> incidence rate was 10.41%, and there was no significant difference among the age groups; thus, women with other types of viral infections, regardless of age, should be referred to colposcopy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Although <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>16 is the <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> with the highest risk, other <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> infections can also cause a high percentage of <jats:styled-content style=\"fixed-case\">HSIL<\/jats:styled-content>s and <jats:styled-content style=\"fixed-case\">SCC<\/jats:styled-content> in women with normal cytology. Therefore, it is necessary to refer <jats:styled-content style=\"fixed-case\">HR<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010infected women aged \u226521\u00a0years for colposcopy in a timely manner to exclude potential cervical intraepithelial neoplasia and cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12717","type":"journal-article","created":{"date-parts":[[2019,5,9]],"date-time":"2019-05-09T08:46:41Z","timestamp":1557391601000},"page":"419-425","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Incidence of cervical high\u2010grade squamous intraepithelial lesions and squamous cell carcinoma in women with high\u2010risk human papillomavirus and normal cervical cytology: A retrospective analysis of 1858 cases stratified by age and human papillomavirus genotype"],"prefix":"10.1111","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3494-9105","authenticated-orcid":false,"given":"Liying","family":"Gu","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Renji Hospital Shanghai Jiaotong University Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology School of Medicine Renji Hospital Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zubei","family":"Hong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology School of Medicine Renji Hospital Shanghai Jiaotong University Shanghai China"},{"name":"Shanghai Key Laboratory of Gynecologic Oncology School of Medicine Renji Hospital Shanghai Jiaotong University Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of 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