{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T09:30:34Z","timestamp":1761989434483,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,7]],"date-time":"2020-02-07T00:00:00Z","timestamp":1581033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Fibroblastic\/myofibroblastic tumors constitute 12% of all pediatric soft tissue tumors with the majority of them belonging to the benign and intermediate prognostic categories. They are often misdiagnosed owing to their variable clinical presentation and unusual microscopic features. The diagnosis, specially cytological diagnosis of benign and intermediate categories is difficult due to paucity of cellular component and increased amount of extracellular matrix as compared to malignant ones. We hereby discuss the Fine needle aspiration cytology (<jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content>) findings of non\u2010malignant fibroblastic\/myofibroblastic lesion in the pediatric age group encountered at our institute.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>All the benign and intermediate fibroblastic\/myofibroblastic\/fibroadipocytic lesions (age 0\u201012\u00a0years) diagnosed on <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> over a period of 3\u00bd\u00a0years (Jan 2016\u2010 July 2019), with availability of corresponding histopathology were included in the study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of seven pediatric benign and intermediate fibroblastic\/myofibroblastic lesions with histopathological confirmation were identified which included Infantile digital fibromatosis (<jats:styled-content style=\"fixed-case\">IDF<\/jats:styled-content>) (n\u00a0=\u00a02), Lipofibromatosis (n\u00a0=\u00a01), Fibrous hamartoma of infancy (<jats:styled-content style=\"fixed-case\">FHI<\/jats:styled-content>) (n\u00a0=\u00a01), Fibromatosis colli (<jats:styled-content style=\"fixed-case\">FC<\/jats:styled-content>) (n\u00a0=\u00a02) and myofibroma\/myofibromatosis (n\u00a0=\u00a01). <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> smears were mainly paucicellular with presence of benign spindle shaped cells in a collagenous stroma common to almost all the cases. A few additional findings such as degenerated skeletal muscle fibres, muscle giant cells and mature adipose tissue were also present in some cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fibroblastic\/myofibroblastic tumors although uncommon, form an important category that must be considered in the differential diagnosis of pediatric soft tissue tumors. <jats:styled-content style=\"fixed-case\">FNAC<\/jats:styled-content> cytology features when assessed in a proper clinical setting (specially the age and site of presentation) are helpful in suggesting probable preoperative diagnosis in these lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12786","type":"journal-article","created":{"date-parts":[[2020,2,8]],"date-time":"2020-02-08T01:11:28Z","timestamp":1581124288000},"page":"115-121","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Non\u2010malignant fibroblastic\/myofibroblastic tumors in pediatric age group: Clues and pitfalls to the cytological diagnosis"],"prefix":"10.1111","volume":"31","author":[{"given":"Harshita","family":"Agarwal","sequence":"first","affiliation":[{"name":"Department of Pathology Chacha Nehru Bal Chikitsalaya  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2352-6975","authenticated-orcid":false,"given":"Lavleen","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology Chacha Nehru Bal Chikitsalaya  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natasha","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Chacha Nehru Bal Chikitsalaya  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mamta","family":"Sengar","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery Chacha Nehru Bal Chikitsalaya  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,7]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAT.0000000000000050"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840080116"},{"key":"e_1_2_7_4_1","first-page":"301","article-title":"Fibroblasts and myofibroblasts in wound healing","volume":"7","author":"Darby IA","year":"2014","journal-title":"Clin Cosmet Investig Dermatol"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.2350\/10-12-0944-PB.1"},{"volume-title":"Enzinger and Weiss's Soft Tissue Tumors","year":"2014","author":"Goldblum JR","key":"e_1_2_7_6_1"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00186121"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12734"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12749"},{"key":"e_1_2_7_10_1","first-page":"1","article-title":"Lipofibromatosis. Fetal and pediatric","author":"Rastogi K","year":"2019","journal-title":"Pathology"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/SAP.0b013e31816d8236"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0492-RS"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000330679"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200011000-00004"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00256-008-0458-z"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jpedsurg.2012.02.009"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.97164"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21316"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12786","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.12786","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12786","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,6]],"date-time":"2023-09-06T23:56:44Z","timestamp":1694044604000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12786"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,2,7]]},"references-count":17,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,3]]}},"alternative-id":["10.1111\/cyt.12786"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12786","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"type":"print","value":"0956-5507"},{"type":"electronic","value":"1365-2303"}],"subject":[],"published":{"date-parts":[[2020,2,7]]},"assertion":[{"value":"2019-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-10-31","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-07","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}