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This case was diagnosed by cytology and confirmed by immunocytochemistry in cerebrospinal fluid smears. <jats:styled-content style=\"fixed-case\">MRI<\/jats:styled-content> findings favored malignancy such as lymphoma and germinoma. As beta\u2010\u0397<jats:styled-content style=\"fixed-case\">CG<\/jats:styled-content> was elevated in serum and cerebrospinal fluid, lymphoma was ruled out and histological confirmation of the diagnosis of germinoma was not necessary. The presence of <jats:styled-content style=\"fixed-case\">AFP<\/jats:styled-content> positive, \u03b2<jats:styled-content style=\"fixed-case\">HCG<\/jats:styled-content> positive, c\u2010kit positive, and <jats:styled-content style=\"fixed-case\">PLAP<\/jats:styled-content> positive cells, established the diagnosis.<\/jats:p>","DOI":"10.1111\/cyt.12792","type":"journal-article","created":{"date-parts":[[2019,12,2]],"date-time":"2019-12-02T10:10:51Z","timestamp":1575281451000},"page":"153-157","update-policy":"http:\/\/dx.doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytological diagnosis of primary pineal germ cell tumour with a yolk sac component in cerebrospinal fluid"],"prefix":"10.1111","volume":"31","author":[{"given":"Alexandra","family":"Kalogeraki","sequence":"first","affiliation":[{"name":"Department of Cytopathology University Hospital of Heraklion  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dimitrios","family":"Tamiolakis","sequence":"additional","affiliation":[{"name":"Department of Cytopathology University Hospital of Heraklion  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nikolaos","family":"Katzilakis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University Hospital of Heraklion  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iordanis","family":"Pelagiadis","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University Hospital of Heraklion  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria","family":"Raissaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Radiology University Hospital of Heraklion  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eftichia","family":"Stiakaki","sequence":"additional","affiliation":[{"name":"Department of Pediatric Hematology\u2010Oncology University Hospital of Heraklion  Heraklion Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,1,21]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nos155"},{"key":"e_1_2_6_3_1","doi-asserted-by":"publisher","DOI":"10.3171\/jns.1991.74.4.0545"},{"key":"e_1_2_6_4_1","volume-title":"WHO Classification of Tumours of the Central Nervous System","author":"Louis DN","year":"2016"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2005-837582"},{"key":"e_1_2_6_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-013-1114-6"},{"issue":"3","key":"e_1_2_6_7_1","first-page":"1719","article-title":"Primary central nervous system germ cell tumors: a review and update","volume":"6","author":"Fetcko K","year":"2018","journal-title":"Med Res Arch"},{"key":"e_1_2_6_8_1","first-page":"549","volume-title":"Pediatric Neurosurgery","author":"Lapras C","year":"1999"},{"issue":"5","key":"e_1_2_6_9_1","first-page":"335","article-title":"Combined chemotherapy and radiation therapy for intracranial germinomas. 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