{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:01Z","timestamp":1747184221274,"version":"3.40.5"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,2,19]],"date-time":"2020-02-19T00:00:00Z","timestamp":1582070400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2020,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Primary human papillomavirus (<jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>) screening, testing for the virus responsible for 99% of cervical cancers, was introduced in 2018\u20102020 in the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content>. This was preceded by <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> triage of low\u2010grade cytology from 2012. Much of the evidence incorporated into current National Health Service (<jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content>) colposcopy guidance assessed outcomes prior to this change in screening. The aim of this paper is to assess adherence to <jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content> cervical screening programme standards, determine the incidence of cases reported as high\u2010risk <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content> plus borderline nuclear change in endocervical cells, to calculate colposcopic accuracy and assess histological outcomes in this cohort.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>A retrospective audit of women referred to a colposcopy clinic in one <jats:styled-content style=\"fixed-case\">NHS<\/jats:styled-content> trust from 2016 to 2018. Data relating to histological outcomes, cytological follow\u2010up and demographics were collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 2001 referrals, 22 data sets identifying <jats:styled-content style=\"fixed-case\">HPV<\/jats:styled-content>\u2010positive borderline endocervical change were eligible for analysis (1.2% incidence). Median age was 29.5. Two\u2010thirds (68.2%, n = 15) had high\u2010grade dysplasia at diagnostic biopsy. Those women with reassuring histology had normal cytological follow\u2010up. Colposcopic accuracy was moderate (positive predictive value 43.8%, negative predictive value 100%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Borderline nuclear change in endocervical cells is an uncommon condition but should be treated as a high\u2010grade referral. All women should be offered a diagnostic biopsy at the initial colposcopy; if no histopathological abnormality is identified, alternative sources of pathology should be considered. Excisional treatment should be recommended to unreliable attenders, those with a complete family and inadequate colposcopy (<jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content>3) and considered in younger women with a <jats:styled-content style=\"fixed-case\">TZ<\/jats:styled-content>3.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12803","type":"journal-article","created":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T23:53:44Z","timestamp":1580342024000},"page":"130-135","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["An audit of liquid\u2010based cytology samples reported as high\u2010risk human papillomavirus and borderline nuclear change in endocervical cells"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8415-7758","authenticated-orcid":false,"given":"Kristyn M.","family":"Manley","sequence":"first","affiliation":[{"name":"Royal United Hospitals Bath NHS Trust  Bath,  UK"},{"name":"University of Bristol  Bristol UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Russell","family":"Luker","sequence":"additional","affiliation":[{"name":"Royal United Hospitals Bath NHS Trust  Bath,  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claire","family":"Park","sequence":"additional","affiliation":[{"name":"Royal United Hospitals Bath NHS Trust  Bath,  UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,2,19]]},"reference":[{"doi-asserted-by":"publisher","key":"e_1_2_10_2_1","DOI":"10.1111\/j.1365-2303.2008.00585.x"},{"doi-asserted-by":"publisher","key":"e_1_2_10_3_1","DOI":"10.1038\/bjc.2014.340"},{"doi-asserted-by":"publisher","key":"e_1_2_10_4_1","DOI":"10.1086\/657321"},{"doi-asserted-by":"publisher","key":"e_1_2_10_5_1","DOI":"10.1038\/bjc.2011.326"},{"unstructured":"NHS Cancer Screening Programme (NHSCSP) Publication 20.Colposcopy and programme management: guidelines for the NHS cervical screening programme.2016; 3rd Edition).https:\/\/www.bsccp.org.uk\/assets\/file\/uploads\/resources\/NHSCSP_20_Colposcopy_and_Programme_Management_(3rd_Edition)_(2).pdf. 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