{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T15:38:18Z","timestamp":1789141098755,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,3,17]],"date-time":"2020-03-17T00:00:00Z","timestamp":1584403200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> Royal College of Pathologists (<jats:styled-content style=\"fixed-case\">RCP<\/jats:styled-content>ath) Thy terminology is an internationally recognised system for reporting thyroid fine needle aspiration. The terminology has been used throughout the UK and Ireland, in some parts of Italy and Switzerland, and elsewhere in the world. There is no systematic review of the literature specifically addressing the use of the <jats:italic>non\u2010diagnostic for cytological<\/jats:italic> diagnosis<jats:italic>\u2010Thy1\/Thy 1c<\/jats:italic> category in the <jats:styled-content style=\"fixed-case\">UK RCP<\/jats:styled-content>ath terminology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive literature search of online databases was conducted in October 2019 specifically examining overall reported rates of Thy1 and Thy1c in aspirates classified according to the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> <jats:italic>Thy<\/jats:italic> terminology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010five articles were identified showing a Thy1 rate of 13.4% (2540\/18\u00a0920). The studies were then stratified according to whether or not the patients underwent rapid on\u2010site evaluation (<jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content>): 6.0% (353\/5841; range 3.0%\u201010.9%) of <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> aspirates were Thy1 whereas 18.5% (2072\/11\u00a0204; range 7.9%\u201043.3%) of non\u2010<jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> patients were Thy1; (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Three studies from 2016 reported Thy1c rates of 5.4%, 6.5% and 10.6%, respectively, implying Thy1 rates excluding Thy1c aspirates of 20.9%, 8.7% and 12.7%, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This systematic review of the literature shows relatively high rates of aspirates <jats:italic>non\u2010diagnostic for cytological diagnosis\u2010Thy1<\/jats:italic> in the peer\u2010reviewed published literature using the <jats:styled-content style=\"fixed-case\">UK<\/jats:styled-content> terminology. Utilisation of <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> appears to produce lower rates of Thy1 aspirates and <jats:styled-content style=\"fixed-case\">ROSE<\/jats:styled-content> should be considered if rates of <jats:italic>non\u2010diagnostic for cytological diagnosis\u2010Thy1\/Thy 1c<\/jats:italic> are high.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12804","type":"journal-article","created":{"date-parts":[[2020,1,31]],"date-time":"2020-01-31T06:46:00Z","timestamp":1580453160000},"page":"502-508","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Rates of <i>Thy 1\u2010non\u2010diagnostic<\/i> thyroid fine needle aspiration using the <scp>UK<\/scp> Royal College of Pathologists Thy Terminology. A systematic review of the literature comparing patients who undergo rapid on\u2010site evaluation and those who do not"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1926-4631","authenticated-orcid":false,"given":"David N.","family":"Poller","sequence":"first","affiliation":[{"name":"Department of Pathology Queen Alexandra Hospital  Cosham Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria","family":"Doyle","sequence":"additional","affiliation":[{"name":"Department of Pathology Queen Alexandra Hospital  Cosham Portsmouth UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierpaolo","family":"Trimboli","sequence":"additional","affiliation":[{"name":"Clinic for Nuclear Medicine and Competence Centre for Thyroid Diseases Imaging Institute of Southern Switzerland Cantonal Hospital Authority  Bellinzona Switzerland"},{"name":"Faculty of Biomedical Sciences Universita della Svizzera Italiana (USI)  Lugano Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Massimo","family":"Bongiovanni","sequence":"additional","affiliation":[{"name":"Department of Pathology Synlab Suisse SA  Lausanne Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,3,17]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199607)15:1<84::AID-DC18>3.0.CO;2-8"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(20000825)90:4<239::AID-CNCR7>3.0.CO;2-S"},{"key":"e_1_2_8_4_1","first-page":"149","article-title":"Thyroid aspiration cytology in Newcastle: a six year cytology\/histology correlation study","volume":"82","author":"Tabaqchali MA","year":"2000","journal-title":"Ann R Coll Surg Engl"},{"key":"e_1_2_8_5_1","volume-title":"Guidelines for the Management of Thyroid Cancer in Adults","author":"British Thyroid Association & Royal College of 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