{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T10:24:17Z","timestamp":1778495057641,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,6,14]],"date-time":"2020-06-14T00:00:00Z","timestamp":1592092800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Ministry of Health of the Czech Republic-Conceptual Development of Research Organization Faculty Hospital in Pilsen","award":["FNPl00669806"],"award-info":[{"award-number":["FNPl00669806"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"Abstract<\/jats:title>Background<\/jats:title>It is generally acknowledged that interobserver variability for the histological diagnosis of endocervical adenocarcinoma (EA<\/jats:styled-content>) subtypes is suboptimal. The recently proposed International Endocervical Adenocarcinoma Criteria and Classification (IECC<\/jats:styled-content>) system is based on the presence of associated human papilloma virus (HPV<\/jats:styled-content>) infection. It recognises HPV<\/jats:styled-content>\u2010associated EA<\/jats:styled-content>s and non\u2010HPV<\/jats:styled-content>\u2010associated EA<\/jats:styled-content>s.<\/jats:p><\/jats:sec>Methods<\/jats:title>This prospective cytology\u2010histology and molecular genetics\u2010based study investigated the potential effect of IECC<\/jats:styled-content> being applied to Papanicolaou (Pap) test with regard to the diagnostic accuracy of severe glandular lesions reported at least as adenocarcinoma in situ (AIS<\/jats:styled-content>).<\/jats:p><\/jats:sec>Results<\/jats:title>Out of 118 liquid\u2010based cytology Pap tests with AIS<\/jats:styled-content>+ lesion, complete information on follow\u2010up biopsy and HPV<\/jats:styled-content> status was available in 51 cases. AIS<\/jats:styled-content> and EA<\/jats:styled-content> category correlated with histologically confirmed AIS<\/jats:styled-content>\/EA<\/jats:styled-content> in 88.5% (23\/26) and 70.5% (12\/17) of cases, respectively. Interestingly, 93% (40\/43) of cases diagnosed as AIS<\/jats:styled-content>\/EA<\/jats:styled-content> were HPV<\/jats:styled-content> positive and 7% (3\/43) were HPV<\/jats:styled-content> negative (originating in the cervix, endometrium and adnexa).<\/jats:p><\/jats:sec>Conclusions<\/jats:title>Our findings suggest that this approach could possibly divide Pap tests containing severe glandular lesion into two groups: (a) robust diagnosis of HPV<\/jats:styled-content>\u2010associated EA<\/jats:styled-content> and (b) non\u2010HPV<\/jats:styled-content> associated glandular lesions of heterogeneous origin, requiring further clinical preoperative diagnostic workup.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12831","type":"journal-article","created":{"date-parts":[[2020,4,14]],"date-time":"2020-04-14T19:21:18Z","timestamp":1586892078000},"page":"288-291","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The newly proposed International Endocervical Adenocarcinoma Criteria and Classification and its relevance to cervical cytology screening assessed in a prospective 2\u2010year study of 118 cases"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4038-5641","authenticated-orcid":false,"given":"Ondrej","family":"Ondi\u010d","sequence":"first","affiliation":[{"name":"Department of Pathology Medical Faculty Charles University Hospital Pilsen Charles University Pilsen Czech Republic"},{"name":"Bioptick\u00e1 laborato\u0159, s.r.o. Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jana","family":"N\u011bmcov\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical Faculty Charles University Hospital Pilsen Charles University Pilsen Czech Republic"},{"name":"Bioptick\u00e1 laborato\u0159, s.r.o. Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Reza","family":"Alaghehbandan","sequence":"additional","affiliation":[{"name":"Department of Pathology Royal Columbian Hospital University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate\u0159ina","family":"\u010cern\u00e1","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical Faculty Charles University Hospital Pilsen Charles University Pilsen Czech Republic"},{"name":"Bioptick\u00e1 laborato\u0159, s.r.o. Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barbora","family":"Gomol\u010d\u00e1kov\u00e1","sequence":"additional","affiliation":[{"name":"Bioptick\u00e1 laborato\u0159, s.r.o. Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iva","family":"Kinkorov\u00e1\u2010Lu\u0148\u00e1\u010dkov\u00e1","sequence":"additional","affiliation":[{"name":"Bioptick\u00e1 laborato\u0159, s.r.o. Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jan","family":"Chytra","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics Medical Faculty Charles University Hospital Pilsen Charles University Pilsen Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrieta","family":"\u0160idlov\u00e1","sequence":"additional","affiliation":[{"name":"Cytopathos, s.r.o. 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