{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T06:23:50Z","timestamp":1773037430023,"version":"3.50.1"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T00:00:00Z","timestamp":1589932800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>In the UK, guidelines from the Royal College of Pathologists (RCPath) facilitate consistent and reproducible reporting and classification of fine needle aspiration cytology (FNAC) thyroid specimens. The aim was to audit our department against RCPath guidelines to refine and improve our reporting process.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Two\u2010cycle retrospective observational audit of all patients undergoing thyroid FNAC over a 2\u2010year period (1\u00a0year for each cycle). Final histology was correlated. The positive predictive value (PPV) for malignant neoplastic lesions was calculated; for Thy1, Thy1c, Thy2 and Thy2c all cases without final histology were assumed to be benign, while for Thy3a, Thy3f, Thy4 and Thy5 samples the PPV calculation was based only on those cytology samples with corresponding histology. False positive and false negative cases were reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, 288 cytology samples were included in the first cycle; 96 (33.3%) had corresponding histology. There were 287 samples included in the second cycle; 119 (41.5%) had follow\u2010up histology. The rate of non\u2010diagnostic samples (Thy1\/1c) decreased from 39.6% to 30.0%. The PPV for malignant neoplastic lesions was Thy1\/1c 2.6%, Thy2\/2c 0.0%, Thy3a 40.0%, Thy3f 19.4%, Thy4 75.0%, Thy5 100.0% (first cycle); Thy1\/1c 4.7%, Thy2\/2c 0.7%, Thy3a 13.3%, Thy3f, 7.7%, Thy4, 50.0%, Thy5 100.0% (second cycle).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our department was able to reduce the rate of non\u2010diagnostic FNAC samples and improve the diagnostic accuracy of FNAC. Auditing local outcomes helps refine and improve the reporting process. Review of false positive and false negative cases helps examine potential pitfalls of cytology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12834","type":"journal-article","created":{"date-parts":[[2020,4,17]],"date-time":"2020-04-17T10:58:40Z","timestamp":1587121120000},"page":"514-524","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Improving our departmental reporting of thyroid cytology specimens against national guidelines: A two\u2010cycle retrospective audit"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8840-9454","authenticated-orcid":false,"given":"Edwin","family":"Halliday","sequence":"first","affiliation":[{"name":"Department of ENT Shrewsbury and Telford Hospital NHS Trust Royal Shrewsbury Hospital  Shrewsbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eleanor","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Shrewsbury and Telford Hospital NHS Trust Royal Shrewsbury Hospital  Shrewsbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hugh","family":"Sansom","sequence":"additional","affiliation":[{"name":"Department of Radiology Shrewsbury and Telford Hospital NHS Trust Royal Shrewsbury Hospital  Shrewsbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Syed Farhan","family":"Ahsan","sequence":"additional","affiliation":[{"name":"Department of ENT Shrewsbury and Telford Hospital NHS Trust Royal Shrewsbury Hospital  Shrewsbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Katherine","family":"Harrison","sequence":"additional","affiliation":[{"name":"Department of Cellular Pathology Shrewsbury and Telford Hospital NHS Trust Royal Shrewsbury Hospital  Shrewsbury UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,5,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12515"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.2373050220"},{"key":"e_1_2_8_4_1","volume-title":"Guidance on the reporting of thyroid cytology specimens (G089)","author":"Cross P","year":"2016"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.f4706"},{"key":"e_1_2_8_6_1","first-page":"252","volume-title":"The Bethesda System for Reporting Thyroid Cytopathology: definitions, Criteria, and Explanatory Notes","author":"Ali SZ","year":"2017"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-014-0062-0"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21517"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215106000703"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.4274\/jcrpe.v2i2.78"},{"issue":"1","key":"e_1_2_8_11_1","first-page":"70","article-title":"Profile of fine needle aspiration cytology of thyroid nodule and its histopathological correlation","volume":"16","author":"Raina B","year":"2011","journal-title":"JK\u2010Practitioner"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP14303.OR"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00423-008-0366-7"},{"key":"e_1_2_8_14_1","unstructured":"JohnsonS.An audit of reporting of thyroid cytology specimens and their correlation with thyroid histology. The Royal College of Pathologists. July2019.https:\/\/www.rcpath.org\/profe\u200bssion\/\u200bquali\u200bty-impro\u200bvemen\u200bt\/condu\u200bcting-a-clini\u200bcal-audit\/\u200bclini\u200bcal-audit-templ\u200bates.html. Accessed December 12 2019."},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1136\/jclinpath-2016-204022"},{"key":"e_1_2_8_16_1","unstructured":"YongAW.Ultrasound guided fine needle aspiration (FNA) of thyroid nodules. The Royal College of Radiologists. March2014.https:\/\/www.rcr.ac.uk\/audit\/\u200bultra\u200bsound-guided-fine-needle-aspir\u200bation-fna-thyro\u200bid-nodules. 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