{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:13Z","timestamp":1747184233449,"version":"3.40.5"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,9,12]],"date-time":"2020-09-12T00:00:00Z","timestamp":1599868800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Atypical polypoid adenomyomas (APAs) are uncommon tumours consisting of atypical endometrioid glands and fibromyomatous stroma. Identifying the biphasic nature of atypical glandular components and spindle mesenchymal components without atypia is crucial for the cytological diagnosis of APA. We investigated the utility of lesion\u2010targeted cytology (LTC) to directly collect firm spindle components.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We recruited seven consecutive surgical patients who underwent cytological examinations before surgery and were diagnosed with APA on postoperative histological examinations. Cytological smears were obtained by routine sampling in five cases and by targeted sampling using transvaginal ultrasonography, that is, LTC, in two cases. We retrospectively analysed the cytological findings from our cases and compared them to those of APA cases previously reported in the English literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 5\/7 cases that involved routine cytological sampling, normal cytological findings were found in 2 and atypical glandular cells were found in 3, but spindle cells from mesenchymal components were not detected. In contrast, among 2\/7 cases in which sampling involved LTC, spindle cells without atypia, in addition to atypical glandular cells were found.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Lesion\u2010targeted cytology is useful to assess mesenchymal components of APAs and may improve the cytological diagnosis of APA.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12899","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T07:48:31Z","timestamp":1597132111000},"page":"579-585","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Lesion\u2010targeted cytology to improve cytological sampling for atypical polypoid adenomyomas of the uterus: A case series and review of the literature"],"prefix":"10.1111","volume":"31","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4430-5490","authenticated-orcid":false,"given":"Makiko","family":"Omori","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Masataka","family":"Kawai","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatsuyuki","family":"Ogawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satoko","family":"Sasatsu","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiroko","family":"Fukasawa","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kumiko","family":"Nakazawa","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tetsuo","family":"Kondo","sequence":"additional","affiliation":[{"name":"Department of Pathology Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuji","family":"Hirata","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Faculty of Medicine University of Yamanashi  Yamanashi Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,9,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198107000-00006"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/86.2.139"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2559.1995.tb00288.x"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199601000-00001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ygyno.2012.12.040"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejogrb.2019.02.027"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/aogs.13553"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(20000301)22:3<176::AID-DC9>3.0.CO;2-H"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21263"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23665"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12673"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0221088"},{"key":"e_1_2_8_14_1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1080\/01443619750113401","article-title":"Atypical polypoid adenomyoma of the uterus: clinical and histological findings of three postmenopausal cases","volume":"17","author":"Sugiyama T","year":"1997","journal-title":"J Obstet Gynaecol"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1006\/gyno.1998.5137"},{"issue":"4","key":"e_1_2_8_16_1","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1159\/000331158","article-title":"Exfoliative cytology of atypical polypoid adenomyoma. A case report","volume":"43","author":"Baschinsky D","year":"1999","journal-title":"Acta Cytol"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1525-1438.2001.011004326.x"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1526-0976.2002.61007.x"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1159\/000326518"},{"key":"e_1_2_8_20_1","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1080\/01443610310000106000","article-title":"Atypical polypoid adenomyoma of the uterine cervix: a diagnostic problem","volume":"23","author":"Ramos P","year":"2003","journal-title":"J Obstet Gynaecol"},{"key":"e_1_2_8_21_1","first-page":"298","article-title":"A case of endometrial carcinoma arising in a 36\u2010year\u2010old woman with uterine atypical polypoid adenomyoma (APA)","volume":"29","author":"Bakalianou K","year":"2008","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_8_22_1","first-page":"701","article-title":"Incidental diagnosis of atypical polypoid adenomyoma in a young infertile woman","volume":"30","author":"Dinas K","year":"2009","journal-title":"Eur J Gynaecol Oncol"},{"key":"e_1_2_8_23_1","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.gynor.2011.12.004","article-title":"Coexisting atypical polypoid adenomyoma and endometrioid endometrial carcinoma in a young woman with Cowden Syndrome: case report and implications for screening and prevention","volume":"2","author":"Edwards JM","year":"2012","journal-title":"Gynecol Oncol Case Rep"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1097\/RCT.0000000000000169"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1111\/jog.12645"},{"key":"e_1_2_8_26_1","doi-asserted-by":"crossref","first-page":"6129","DOI":"10.4081\/rt.2016.6129","article-title":"Positron emission tomography findings in atypical polypoid adenomyoma","volume":"8","author":"Fukami T","year":"2016","journal-title":"Rare Tumors"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tjog.2017.12.019"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000001320"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fcyt.12899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12899","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.12899","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12899","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,4]],"date-time":"2023-09-04T15:51:23Z","timestamp":1693842683000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12899"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,12]]},"references-count":27,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/cyt.12899"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12899","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"type":"print","value":"0956-5507"},{"type":"electronic","value":"1365-2303"}],"subject":[],"published":{"date-parts":[[2020,9,12]]},"assertion":[{"value":"2020-03-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-03","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-12","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}