{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,13]],"date-time":"2026-05-13T08:53:09Z","timestamp":1778662389193,"version":"3.51.4"},"reference-count":26,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,10,25]],"date-time":"2020-10-25T00:00:00Z","timestamp":1603584000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To examine conventional sputum smears for the presence of corpora amylacea (CA), determining their incidence and clinical significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective 4\u2010year cohort study was undertaken of sputum samples from 1176 consecutive patients for the presence of CA. Variables such as age, sex, smoking status, and the presence or absence of haemoptysis were extracted from the medical record. A random group of 50 patients was selected as a control group, and a random group of 50 patients whose ages were below 49\u00a0years was also included as an age\u2010based control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 1075 of the initial cohort of consecutive patients were included in the study. from these, there were 6898 sputum smears, of which 1.91% (132 smears) contained CA, corresponding to 9.86% of the cohort of patients (106 patients). There was a strong, positive, statistically significant correlation between age and CA presence (<jats:italic>\u03c4<\/jats:italic><jats:sub>b<\/jats:sub>\u00a0=\u00a0.402, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001), which supports that CA are associated with older patients. The results of a binary logistic regression indicated that there was a significant association between age, diagnosis of chronic obstructive pulmonary disease and CA presence (\u03c7<jats:sup>2<\/jats:sup>\u00a0=\u00a049.051, <jats:italic>df<\/jats:italic>\u00a0=\u00a02, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The presence of CA in sputum smears is related to age, being much more frequent in older people. Moreover, CA are related to non\u2010neoplastic lung diseases.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12919","type":"journal-article","created":{"date-parts":[[2020,9,29]],"date-time":"2020-09-29T05:44:54Z","timestamp":1601358294000},"page":"108-114","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Corpora amylacea in sputum smears: Incidence and clinical significance"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8972-2434","authenticated-orcid":false,"given":"Rafael","family":"Mart\u00ednez\u2010Gir\u00f3n","sequence":"first","affiliation":[{"name":"INCL\u00cdNICA Foundation for Clinical, Pneumological and Carcinogenic Research Oviedo Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Liron","family":"Pantanowitz","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Clinical Labs University of Michigan Ann Arbor MI USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,25]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep41807"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF01879407"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.56.1.74"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(11)80235-9"},{"key":"e_1_2_11_6_1","first-page":"230","article-title":"Case report: Immunohistochemical characterization of pulmonary corpora amylacea in an autopsy case, with special reference to its pathogenesis","volume":"21","author":"Ohtsuki Y","year":"2010","journal-title":"Biomed Res"},{"key":"e_1_2_11_7_1","first-page":"153","article-title":"Histopathological study of corpora amylacea pulmonum","volume":"4","author":"Dobashi M","year":"1989","journal-title":"Histol Histopathol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.1700740108"},{"key":"e_1_2_11_9_1","first-page":"629","article-title":"Central spherules in pulmonary corpora amylacea","volume":"102","author":"Hollander DH","year":"1978","journal-title":"Arch Pathol Lab Med"},{"issue":"11","key":"e_1_2_11_10_1","doi-asserted-by":"crossref","first-page":"900","DOI":"10.2169\/internalmedicine.38.900","article-title":"Immunohistochemical study of a patient with diffuse pulmonary corpora amylacea detected by open lung biopsy","volume":"38","author":"Yamanouchi H","year":"1999","journal-title":"Intern Med"},{"key":"e_1_2_11_11_1","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1007\/978-1-4899-7396-2","volume-title":"Pulmonary cytopathology","author":"Erozan YS","year":"2014"},{"key":"e_1_2_11_12_1","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1007\/978-0-387-21641-6","volume-title":"Color Atlas of pulmonary cytopathology","author":"Kini SR","year":"2002"},{"key":"e_1_2_11_13_1","first-page":"68","volume-title":"Respiratory tract and mediastinum","author":"French CA","year":"2014"},{"key":"e_1_2_11_14_1","first-page":"258","volume-title":"Comprehensive cytopathology","author":"Solomides CC","year":"2015"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0344-0338(96)80041-0"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.expneurol.2014.01.006"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-005-5784-z"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-28231-1"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800250"},{"key":"e_1_2_11_20_1","first-page":"1071","article-title":"Corpora amylacea in the brain form highly branched three\u2010dimensional lattices","volume":"55","author":"Pirici I","year":"2014","journal-title":"Rom J Morphol Embryol"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331286"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23120"},{"key":"e_1_2_11_23_1","first-page":"6","volume-title":"Pulmonary pathology","author":"Flieder DB","year":"2017"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1183\/09059180.00001311"},{"key":"e_1_2_11_25_1","first-page":"511","article-title":"Corpora amylacea in cerebrospinal fluid. A source of possible diagnostic error","volume":"22","author":"Preissig SH","year":"1978","journal-title":"Acta Cytol"},{"key":"e_1_2_11_26_1","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1002\/dc.20087","article-title":"Corpora amylacea in cervicovaginal smears","volume":"31","author":"Mart\u00ednez GR","year":"2004","journal-title":"Diagn Cytopathol"},{"key":"e_1_2_11_27_1","first-page":"412","article-title":"Urine cytology and adjunct markers for detection and surveillance of bladder cancer","volume":"2","author":"Sullivan PS","year":"2010","journal-title":"Am J Transl Res"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12919","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.12919","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12919","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T11:11:41Z","timestamp":1693739501000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12919"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10,25]]},"references-count":26,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2021,1]]}},"alternative-id":["10.1111\/cyt.12919"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12919","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,10,25]]},"assertion":[{"value":"2020-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-09-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-10-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}