{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,22]],"date-time":"2026-09-22T04:18:44Z","timestamp":1790050724802,"version":"4.0.1"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,2,5]],"date-time":"2021-02-05T00:00:00Z","timestamp":1612483200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Lymph node sampling by endobronchial ultrasound\u2010guided transbronchial needle aspiration (EBUS\u2010TBNA) is the state of art procedure for staging the mediastinum and hilar regions in lung cancer patients. Our experience of implementing the real\u2010time cytopathology intervention (RTCI) process for intraoperative EBUS\u2010TBNAs is presented. This study is aimed to describe in detail the RTCI process for EBUS\u2010TBNAs, and assess its utility and diagnostic yield before and after its implementation in parallel to conventional rapid on\u2010site evaluation (c\u2010ROSE).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective review of all EBUS\u2010TBNAs between July 2016 and July 2017 at the University of Rochester Medical Center was performed. Final diagnoses, patient clinical data, and number of non\u2010diagnostic samples (NDS) were reviewed. The numbers of NDS obtained from EBUS\u2010TBNAs with no cytology assistance (NCA), with RTCI and with c\u2010ROSE were analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Non\u2010diagnostic lymph node samples were found in 20 out of 116 (17%), three out of 114 (2.6%) and 33 out of 286 (11.5%) cases with NCA, RTCI and c\u2010ROSE, respectively. Application of statistical analysis revealed significant difference in the NDS between the groups of cases in the operating room with NCA and RTCI (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.005). The different settings and variables between the cases performed using RTCI in the operating room and those assisted with c\u2010ROSE in the bronchoscopy suite preclude legitimate comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results indicate that the use of RTCI could yield a significantly low proportion of NDS when assisting EBUS\u2010TBNA of mediastinal and hilar lymph node for lung cancer patients enhancing the diagnostic efficiency of the procedure.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12956","type":"journal-article","created":{"date-parts":[[2021,2,8]],"date-time":"2021-02-08T05:05:33Z","timestamp":1612760733000},"page":"318-325","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Optimising rapid on\u2010site evaluation\u2010assisted endobronchial ultrasound\u2010guided transbronchial needle aspiration of mediastinal lymph nodes: The real\u2010time cytopathology intervention process"],"prefix":"10.1111","volume":"32","author":[{"given":"Alexandra M.","family":"Danakas","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolyn E.","family":"Jones","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Foregut Surgery Department of Surgery University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Magguilli","sequence":"additional","affiliation":[{"name":"Department of Pathology Oklahoma University Medical Center  Oklahoma City OK USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michal J.","family":"Lada","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Foregut Surgery Department of Surgery University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Plavnicky","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobha","family":"Parajuli","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Cincinnati  Cincinnati OH USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph J.","family":"Wizorek","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Foregut Surgery Department of Surgery University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian G.","family":"Peyre","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Foregut Surgery Department of Surgery University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark","family":"Ettel","sequence":"additional","affiliation":[{"name":"Division of Thoracic and Foregut Surgery Department of Surgery University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Sweeney","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0458-4157","authenticated-orcid":false,"given":"Luis E.","family":"De Las Casas","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Rochester Medical Center  Rochester NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,2,5]]},"reference":[{"issue":"4","key":"e_1_2_9_2_1","first-page":"S359","article-title":"Advanced bronchoscopic techniques in diagnosis and staging of lung cancer","volume":"5","author":"Zaric B","year":"2013","journal-title":"J Thorac Dis"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21431"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2015.11.038"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2012.09.074"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1216"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2017-0114-SA"},{"issue":"2","key":"e_1_2_9_8_1","first-page":"152","article-title":"On\u2010site cytopathologic analysis of bronchoscopic needle aspiration: con: on\u2010site analysis is not indicated","volume":"10","author":"Boyan W","year":"2003","journal-title":"Bronchol Interventional Pulmonol"},{"issue":"2","key":"e_1_2_9_9_1","first-page":"150","article-title":"On\u2010site cytopathologic analysis of bronchoscopic needle aspiration: pro: on\u2010site analysis is indicated","volume":"10","author":"Chin RJ","year":"2003","journal-title":"Bronchol Interventional Pulmonol"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2017.11.004"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2020-0119-CP"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.21037\/jtd.2017.04.12"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.12438"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.10-2914"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10065"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.4103\/jpi.jpi_71_18"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21482"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12956","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.12956","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.12956","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T15:06:08Z","timestamp":1693580768000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.12956"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,2,5]]},"references-count":16,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,5]]}},"alternative-id":["10.1111\/cyt.12956"],"URL":"https:\/\/doi.org\/10.1111\/cyt.12956","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,2,5]]},"assertion":[{"value":"2020-02-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-01-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-02-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}