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Histomorphological findings of IPMN are well established; however, there are not many published papers regarding the cytological findings of IPMN on fine needle aspiration (FNA) specimens. We review the cytomorphological features, molecular profile, imaging findings, and prognosis of IPMN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The English literature was thoroughly searched with key phrases containing IPMN.<\/jats:p><\/jats:sec><jats:sec><jats:title>Observations<\/jats:title><jats:p>IPMN is a rare entity, affecting men and women equally and is usually diagnosed at the age of 60\u201070\u00a0years. The characteristic imaging features include a cystic lesion with associated dilatation of the main or branch pancreatic duct, and atrophy of surrounding pancreatic parenchyma. Cytomorphological features of IPMN include papillary fragments of mucinous epithelium in a background of abundant thick extracellular mucin, a hallmark feature. IPMNs should be evaluated for high\u2010grade dysplasia, which manifests with nuclear atypia, nuclear moulding, prominent nucleoli, nuclear irregularity, and cellular crowding. Molecular profiling of IPMN along with carcinoembryonic antigen and amylase levels is useful in predicting malignancy or high\u2010grade dysplasia arising in IPMN. Overall, the prognosis of IPMN is excellent except in those cases with high\u2010grade dysplasia and malignant transformation. Postoperative surveillance is required for resected IPMNs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>IPMN requires a multidisciplinary approach for management. Cytomorphological findings of IPMN on FNA, in conjunction with tumour markers in pancreatic fluid cytology and imaging findings, are of paramount importance in clinical decision\u2010making for IPMN.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.12973","type":"journal-article","created":{"date-parts":[[2021,4,1]],"date-time":"2021-04-01T11:59:55Z","timestamp":1617278395000},"page":"397-406","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Intraductal papillary mucinous neoplasm of the pancreas: Cytomorphology, imaging, molecular profile, and prognosis"],"prefix":"10.1111","volume":"32","author":[{"given":"Bita","family":"Geramizadeh","sequence":"first","affiliation":[{"name":"Department of Pathology Medical School of Shiraz University Shiraz University of Medical Sciences Shiraz Iran"},{"name":"Transplant Research Center Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mahsa","family":"Marzban","sequence":"additional","affiliation":[{"name":"University of British Columbia Vancouver BC Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5082-8840","authenticated-orcid":false,"given":"Alireza","family":"Shojazadeh","sequence":"additional","affiliation":[{"name":"Department of Pathology Medical School of Shiraz University Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Kadivar","sequence":"additional","affiliation":[{"name":"University of Maryland College Park MD USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3273-4802","authenticated-orcid":false,"given":"Zahra","family":"Maleki","sequence":"additional","affiliation":[{"name":"Division of Cytopathology Department of Pathology The Johns\u2010Hopkins 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