{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T14:30:11Z","timestamp":1782225011707,"version":"3.54.5"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2021,7,12]],"date-time":"2021-07-12T00:00:00Z","timestamp":1626048000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2021,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>To investigate the diagnostic accuracy of a different sample preparation protocol for fine needle aspiration cytology (FNAC) of thyroid nodules established during the COVID\u201019 pandemic.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>From April 2020, conventional smears during FNAC were ceased according to World Health Organization recommendations due to the increased infection risk for operators, and a new protocol using only liquid\u2010based cytology (LBC) was adopted. FNACs performed between April and July 2020 (COVID\u201019 group) were retrospectively compared with those from December 2019 through March 2020 (Pre\u2010COVID\u201019 group). The distribution of diagnoses based on SIAPEC\u2010IAP categories and the concordance between cytological and histological results were compared using the chi\u2010squared test.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Categories based on FNAC for 90 and 82 thyroid nodules in the Pre\u2010COVID\u201019 and COVID\u201019 groups showed no significant difference in distribution (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.081), with the following respective cases (and percentages): TIR1, 7 (8%) and 8 (10%); TIR1C, 0 (0%) and 6 (7%); TIR2, 59 (66%) and<\/jats:p><jats:p>55 (67%); TIR3A, 8 (9%) and 5 (6%); TIR3B, 1 (1%) and 2 (3%); TIR4, 5 (6%) and 1 (1%); and TIR5, 10 (12%) and 5 (7%). Among patients with potentially malignant lesions, surgery was performed for 12\/16 (75%) nodules in the Pre\u2010COVID\u201019 and 7\/8 (88%) nodules in the COVID\u201019 groups, with no significant differences between cytological and histological diagnoses (<jats:italic>P<\/jats:italic> = .931).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The new LBC\u2010only protocol provided similar diagnostic accuracy in comparison with conventional smears, and can be effectively applied during a viral pandemic improving operator safety.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13020","type":"journal-article","created":{"date-parts":[[2021,6,17]],"date-time":"2021-06-17T05:23:15Z","timestamp":1623907395000},"page":"732-737","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Changes in thyroid fine needle aspiration practice during the COVID\u201019 pandemic"],"prefix":"10.1111","volume":"32","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6711-8084","authenticated-orcid":false,"given":"Duccio","family":"Rossi","sequence":"first","affiliation":[{"name":"Postgraduate School of Radiodiagnostics Universit\u00e0 Degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Belotti","sequence":"additional","affiliation":[{"name":"Postgraduate School of Pathology Universit\u00e0 Degli Studi di Milano Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clementina","family":"di Tonno","sequence":"additional","affiliation":[{"name":"Division of Cytopathology IEO European Institute of Oncology IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valeria","family":"Midolo","sequence":"additional","affiliation":[{"name":"Division of Cytopathology IEO European Institute of Oncology IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fausto Antonio","family":"Maffini","sequence":"additional","affiliation":[{"name":"Division of Pathology IEO European Institute of Oncology IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Nicosia","sequence":"additional","affiliation":[{"name":"Department of Breast Radiology IEO European Institute of Oncology IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvio","family":"De Fiori","sequence":"additional","affiliation":[{"name":"Department of Radiology IEO European Institute of Oncology IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4726-2692","authenticated-orcid":false,"given":"Giovanni","family":"Mauri","sequence":"additional","affiliation":[{"name":"Department of Oncology and Hematology\u2010Oncology University of Milan Milan Italy"},{"name":"Division of Interventional Radiology IEO European Institute of Oncology IRCCS Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2021,7,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.maturitas.2016.11.002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdq467"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2013.0045"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2012.0302"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmj.g3045"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9610(87)90254-6"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2009.00709.x"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23541"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/104.2.150"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2012-0009-CP"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.9027"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.2020.4344"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)30154-9"},{"key":"e_1_2_12_15_1","unstructured":"BarbareschiM AscoliV BonoldiE et al.DOCUMENTO SIAPEC\u2010IAP: Gestione del rischio biologico correlato alla epidemia di COVID\u201019 nella manipolazione dei campioni tissutali e citologici con particolare riguardo ai campioni a fresco o non adeguatamente fissati. 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