{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:33Z","timestamp":1747184253053,"version":"3.40.5"},"reference-count":10,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,10,18]],"date-time":"2021-10-18T00:00:00Z","timestamp":1634515200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Extramammary Paget\u2019s disease (EMPD) is a rare neoplasm that commonly affects post\u2010menopausal women. It usually presents in the anogenital area where apocrine sweat glands are abundant, most commonly in the vulva. The disease is characterised by slow growth and high local recurrence rates. Clinically, EMPD presents as well\u2010demarcated erythematous lesions or plaques that may be ulcerated. Microscopically, it shows a group of atypical cells with abundant clear cytoplasm and nuclear pleomorphism.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present the case of a 58\u2010year\u2010old female with\u00a0a history of poorly differentiated squamous cell carcinoma of the cervix, status post\u2010radical\u2010hysterectomy with bilateral salpingo\u2010oophorectomy, and chemoradiation in 2016. The patient also had a long\u2010standing history of vulvar pain, skin changes on her left labia, and itching.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Punch biopsies of the vulva revealed acanthosis and acantholysis of the epidermis with an intraepidermal scattering of single, or clusters of, large cells with round\/oval nuclei and abundant clear cytoplasm. The cells were positive for p16, CK19, CK7, and PAX8, supporting the diagnosis of EMPD without evidence of dysplasia. The concurrent Papanicolaou smear showed a hypercellular specimen composed of hyperchromatic tissue fragments with high nuclear\u2010to\u2010cytoplasmic ratios and apoptotic bodies. The presence of intracytoplasmic mucin and the tridimensionality of the fragments supported the diagnosis of adenocarcinoma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This study compares the histological and cytomorphological features of EMPD with high\u2010grade squamous intraepithelial lesions, since the pathogenesis, precursor lesions, etiological associations, staging, clinical treatment, and prognosis differ substantially and may have a significant clinical impact on the patient's treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13065","type":"journal-article","created":{"date-parts":[[2021,10,6]],"date-time":"2021-10-06T08:21:33Z","timestamp":1633508493000},"page":"384-388","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Cytomorphological features of extramammary Paget\u2019s disease of the vulva in a patient with diagnoses of squamous cell carcinoma of the cervix status post\u2010chemoradiation, and high\u2010grade vulvar intraepithelial neoplasia: The importance of basic principles"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-4104","authenticated-orcid":false,"given":"Maria Fernanda","family":"Gonzalez","sequence":"first","affiliation":[{"name":"Department of Pathology University of Illinois at Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dereen Mohammed","family":"Duhoki","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Illinois at Chicago  Chicago IL USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,10,18]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/IGC.0000000000001189"},{"key":"e_1_2_8_3_1","first-page":"1224","volume-title":"Rosai and Ackerman's Surgical Pathology Book","author":"Gilks B","year":"2018"},{"key":"e_1_2_8_4_1","first-page":"220","volume-title":"Comprehensive Cytopathology","author":"Abdul\u2010Karim FW","year":"2015"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gore.2016.12.010"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21160"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0000000000000602"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0b013e31828487a2"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20153189"},{"key":"e_1_2_8_10_1","first-page":"1","article-title":"Paget disease of the vulva: diagnosis by immunohistochemistry","volume":"2015","author":"Amorium AG","year":"2015","journal-title":"Case Rep Dermatol Med"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000017018"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13065","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.13065","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13065","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,25]],"date-time":"2023-08-25T18:28:46Z","timestamp":1692988126000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.13065"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,10,18]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2022,5]]}},"alternative-id":["10.1111\/cyt.13065"],"URL":"https:\/\/doi.org\/10.1111\/cyt.13065","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"type":"print","value":"0956-5507"},{"type":"electronic","value":"1365-2303"}],"subject":[],"published":{"date-parts":[[2021,10,18]]},"assertion":[{"value":"2021-07-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-01","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-18","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}