{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,5]],"date-time":"2026-05-05T02:05:57Z","timestamp":1777946757402,"version":"3.51.4"},"reference-count":29,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2022,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>The objective of this study was to assess the diagnostic utility of CD10 in the differential diagnosis of grade 1\u2010endometrial endometrioid carcinoma (G1\u2010EEC) and the metaplastic changes associated with the endometrial glandular and stromal breakdown (EGBD) on liquid\u2010based cytological (LBC) samples.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>(1) The type and distribution of CD10\u2010positive cells in EGBD and G1\u2010EEC patients were evaluated. (2) Based on the results from (1), histological and cytological specimens were double\u2010immunostained with CD31 and CD10 to confirm whether CD10\u2010positive tubular\u2010canalicular material found in (1) was represented by fine threads of endometrial\u2010type fibrovascular stroma. (3) Based on the results from (2), additional immunostaining of histological specimens was performed for CD146 and \u03b1SMA as markers of perivascular cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>(1) CD10 positive cells showed two main patterns of expression: cytoplasmic immunoreactivity in the form of dense brown granules in EGBD and tubular\u2010canalicular branching patterns in G1\u2010EEC. (2) The tubular\u2010canalicular material observed in cytological specimens of G1\u2010EEC samples co\u2010expressed CD10 and CD31, and was interpreted as representing fine threads of endometrial fibrovascular stroma in the corresponding histological samples. Conversely, metaplastic changes in EGBD cases, only a few CD31\u2010positive signals were found inside the condensed stromal clusters with CD10\u2010positive. (3) Cells surrounding the CD31\u2010positive vascular endothelial cells expressed CD146 and \u03b1SMA; moreover, some of the thin CD10\u2010positive fibrous stromal strands also co\u2010expressed \u03b1SMA.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>CD10 is a very useful immunomarker for distinguishing between G1\u2010EEC and the metaplastic changes of EGBD in LBC samples.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13070","type":"journal-article","created":{"date-parts":[[2021,10,24]],"date-time":"2021-10-24T17:20:10Z","timestamp":1635096010000},"page":"362-373","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The expression pattern of CD10 and CD31 identifies fine fibrovascular stroma of grade 1\u2010endometrial endometrioid carcinomas in 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