{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T08:43:33Z","timestamp":1778575413964,"version":"3.51.4"},"reference-count":10,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2021,11,17]],"date-time":"2021-11-17T00:00:00Z","timestamp":1637107200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2022,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cholangiocarcinoma is a relatively rare form of adenocarcinoma which may resemble adenocarcinoma of pancreatobiliary origin or adenocarcinomas from many other sites in the body. As a result, its diagnosis relies mainly on clinical history and morphology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Case<\/jats:title><jats:p>A 64\u2010year\u2010old male with cirrhosis and worsening liver failure underwent fine needle aspiration of a radiologically detected liver mass. Cytological material showed a monomorphic population of cells arranged singly and in clusters, reminiscent of a neuroendocrine tumour (NET). Cell block morphology added to the diagnostic dilemma by showing a delicate vasculature among the tumour cells. Immunohistochemistry on the cell block revealed that cells were positive for CK7 and CK19 and negative for synaptophysin and chromogranin, thereby pointing towards a pancreatobiliary origin for the tumour and excluding an NET.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In the case of liver aspirates, even when encountering confusing morphological entities, it is imperative to keep in mind the possibility of a rare neoplasm such as cholangiocarcinoma. In the absence of core needle biopsy, cell block sections prepared from aspirated material can provide appreciable immunohistochemistry results to resolve the diagnostic dilemma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13073","type":"journal-article","created":{"date-parts":[[2021,11,3]],"date-time":"2021-11-03T05:46:05Z","timestamp":1635918365000},"page":"257-260","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Cholangiocarcinoma: A diagnostic dilemma on cytology"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4712-3465","authenticated-orcid":false,"given":"Fatima","family":"Shamsuddin","sequence":"first","affiliation":[{"name":"Department of Cytopathology Mubarak Al\u2010Kabeer Hospital Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3848-4202","authenticated-orcid":false,"given":"Mrinmay Kumar","family":"Mallik","sequence":"additional","affiliation":[{"name":"Department of Cytopathology Mubarak Al\u2010Kabeer Hospital Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sundus","family":"Hussein","sequence":"additional","affiliation":[{"name":"Department of Histopathology Mubarak Al\u2010Kabeer Hospital Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali A.","family":"Alali","sequence":"additional","affiliation":[{"name":"Department of Gastroenterology and Hepatology Mubarak Al\u2010Kabeer Hospital Jabriya Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kusum","family":"Kapila","sequence":"additional","affiliation":[{"name":"Department of Cytopathology Mubarak Al\u2010Kabeer Hospital Jabriya Kuwait"},{"name":"Department of Pathology Faculty of Medicine Kuwait University Safat Kuwait"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2021,11,17]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840020203"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000658-199911000-00008"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(04)00005-9"},{"issue":"6","key":"e_1_2_9_5_1","first-page":"537","article-title":"Cholangiocarcinoma: epidemiology, mechanisms of carcinogenesis and prevention","volume":"2","author":"Parkin DM","year":"1993","journal-title":"Cancer Epidemiol Biomarkers Prev"},{"key":"e_1_2_9_6_1","first-page":"306","article-title":"Cholangiocarcinoma: a review","volume":"5","author":"Thuluvath PJ","year":"1997","journal-title":"Gastroenterologist"},{"key":"e_1_2_9_7_1","first-page":"1221","volume-title":"Odze and Goldblum Surgical Pathology of the GI Tract, Liver, Biliary Tract, and Pancreas","author":"Odze RD","year":"2015"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23849"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/1757-1626-2-90"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.5858\/2000-124-1196-EOCAIC"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-015-0439-1"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13073","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.13073","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13073","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T13:18:05Z","timestamp":1693228685000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.13073"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,17]]},"references-count":10,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2022,3]]}},"alternative-id":["10.1111\/cyt.13073"],"URL":"https:\/\/doi.org\/10.1111\/cyt.13073","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,17]]},"assertion":[{"value":"2021-08-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-10-29","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2021-11-17","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}