{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T04:19:34Z","timestamp":1782879574959,"version":"3.54.5"},"reference-count":24,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,1,28]],"date-time":"2022-01-28T00:00:00Z","timestamp":1643328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To analyse the cytopathological features of fine needle aspiration (FNA) in angioimmunoblastic T\u2010cell lymphoma (AITL) diagnostics.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Fine needle aspiration lymph node biopsy samples from 12 patients with AITL were collected at a single centre between January 2014 and December 2020. The clinical, cytological and histopathological characteristics were retrospectively analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Three male and six female patients with AITL who had a median onset age of 65\u00a0years (range 51\u201074\u00a0years) and a mean follow\u2010up period of 29\u00a0months (range 12\u201047 months) were included. The FNA cytological and morphological analysis of the reactive lymph node background revealed diffusely distributed non\u2010homogeneous mixed lymphocytes, including mature small lymphocytes, medium\u2010sized lymphoid cells, immune cells, and plasma cells; some mixed eosinophils, macrophages, and an occasional mixture of visible and medium\u2010sized lymphocytes and epithelioid cells were observed. Mitotically active lymphocytes and sporadic pigmented bodies were observed occasionally. An abnormal proliferation of follicular dendritic cells observed under the microscope is important for AITL diagnosis, and these cells are often distributed in a scattered pattern of small clusters with many nuclear morphologies. Branched capillaries are another important diagnostic clue. Two patients with AITL who achieved clinical remission after treatment experienced recurrence and were diagnosed using FNA and cell block immunohistochemistry.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Fine needle aspiration provides clues for the diagnosis of AITL in special clinical situations, and cell block immunohistochemistry is worthy of further exploration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13099","type":"journal-article","created":{"date-parts":[[2022,1,17]],"date-time":"2022-01-17T17:21:15Z","timestamp":1642440075000},"page":"499-504","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Cytopathological characteristics of angioimmunoblastic T\u2010cell lymphoma diagnosed by fine needle aspiration"],"prefix":"10.1111","volume":"33","author":[{"given":"Mingjian","family":"Fei","sequence":"first","affiliation":[{"name":"Department of Pathology The Second Affiliated Hospital of Jiaxing University  Jiaxing, 314000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiao","family":"Ye","sequence":"additional","affiliation":[{"name":"Department of Hematology Rheumatology The Second Affiliated Hospital of Jiaxing University  Jiaxing, 314000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology The Second Affiliated Hospital of Jiaxing University  Jiaxing, 314000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianghui","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Hematology Rheumatology The Second Affiliated Hospital of Jiaxing University  Jiaxing, 314000 China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Hematology Rheumatology The Second Affiliated Hospital of Jiaxing 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