{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T20:13:14Z","timestamp":1792181594105,"version":"4.4.0"},"reference-count":37,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2022,5,2]],"date-time":"2022-05-02T00:00:00Z","timestamp":1651449600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2022,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The coronavirus disease 2019 (COVID\u201019) infection caused by the novel severe acute respiratory syndrome corona virus 2 (SARS\u2010CoV\u20102) is associated with a wide range of disease patterns, ranging from mild to life\u2010threatening pneumonia. COVID\u201019 can be associated with a suppressed immune response and\/or hyperinflammatory state due to a cytokine storm. Reduced immunity, combined with steroid usage to prevent a cytokine storm along with various pre\u2010existing comorbidities can prove to be fertile ground for various secondary bacterial and fungal infection, including mucormycosis. Diagnosis of <jats:italic>Mucor<\/jats:italic> is a challenging task given the high negativity rate of various detection methods. While histopathology is considered the gold standard, the acquisition of necessary tissue biopsy specimens requires invasive procedures and is time consuming.<\/jats:p><\/jats:sec><jats:sec><jats:title>Method<\/jats:title><jats:p>In this study five different methods of <jats:italic>Mucor<\/jats:italic> detection, namely conventional cytopathology, liquid\u2010based cytology (LBC, BD SurePath\u2122), potassium hydroxide (KOH) preparation, culture, and histopathology were analysed. The sensitivity, specificity, positive predictive value (PPV), and negative predictive value (NPV) were calculated for all five methods.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>LBC had values for sensitivity, specificity, PPV, and NPV of 72.4%, 100%, 100%, and 38.4%, respectively, closely matching histopathology in sensitivity (75.9%). The sensitivity of culture, conventional cytopathology, and KOH were very low compared to histopathology and LBC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This study showed that LBC, can be a rapid and effective alternative to histopathology in <jats:italic>Mucor<\/jats:italic> diagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13131","type":"journal-article","created":{"date-parts":[[2022,4,18]],"date-time":"2022-04-18T16:13:31Z","timestamp":1650298411000},"page":"454-462","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Sensitivity of liquid\u2010based cytology in the diagnosis of mucormycosis in <scp>COVID<\/scp>\u201019 treated patients"],"prefix":"10.1111","volume":"33","author":[{"given":"Rabish","family":"Kumar","sequence":"first","affiliation":[{"name":"Department of Pathology Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2062-6628","authenticated-orcid":false,"given":"Meeta","family":"Singh","sequence":"additional","affiliation":[{"name":"Department of Pathology Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tanu","family":"Sagar","sequence":"additional","affiliation":[{"name":"Department of Microbiology Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"\u00a0","family":"Bharanidharan","sequence":"additional","affiliation":[{"name":"Department of Pathology Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nita","family":"Khurana","sequence":"additional","affiliation":[{"name":"Department of Pathology Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravi","family":"Meher","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vikas","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Otorhinolaryngology Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruchi","family":"Goel","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonal","family":"Saxena","sequence":"additional","affiliation":[{"name":"Department of Microbiology Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jyoti","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis Maulana Azad Medical College and Associated Hospitals  New Delhi India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2022,5,2]]},"reference":[{"issue":"9","key":"e_1_2_13_2_1","first-page":"e10726","article-title":"Rhino\u2010orbital mucormycosis associated with COVID\u201019","volume":"12","author":"Mehta S","year":"2020","journal-title":"Cureus"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0530-3"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1093\/infdis\/jiaa150"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40618-020-01266-w"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mycmed.2020.100971"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11046-021-00528-2"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/cir866"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-021-07085-3"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmi.2014.12.021"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI73585"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/tmi.13641"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/postgradmedj-2021-140537"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pntd.0009921"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid2709.210934"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/cid\/ciw326"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijgo.2007.07.023"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.22842"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.20599"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2004.0050"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07564-3"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dsx.2021.05.019"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2213-2600(21)00265-4"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2021.105957"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12070-021-02574-0"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2021-241663"},{"issue":"2","key":"e_1_2_13_27_1","doi-asserted-by":"crossref","first-page":"244","DOI":"10.4103\/ijo.IJO_3774_20","article-title":"Mucor in a viral land: a tale of two pathogens","volume":"69","author":"Sen M","year":"2021","journal-title":"Indian J Ophthalmol"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijo.IJO_3763_20"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2454-5929.ijohns20211583"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.18203\/issn.2454-5929.ijohns20211574"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12663-021-01532-1"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0022215121000992"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof6040265"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1086\/588660"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1470-9465.2004.00843.x"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23518"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmicb.2018.02923"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24924"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.13131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,23]],"date-time":"2023-08-23T20:47:09Z","timestamp":1692823629000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.13131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,5,2]]},"references-count":37,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2022,7]]}},"alternative-id":["10.1111\/cyt.13131"],"URL":"https:\/\/doi.org\/10.1111\/cyt.13131","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,5,2]]},"assertion":[{"value":"2022-02-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-04-11","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-02","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}