{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,15]],"date-time":"2026-05-15T01:03:11Z","timestamp":1778806991421,"version":"3.51.4"},"reference-count":33,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2022,6,24]],"date-time":"2022-06-24T00:00:00Z","timestamp":1656028800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2022,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study is the first to analyse the prevalence of oral candidiasis in onco\u2010haematological patients by physical and oral cytopathological examinations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a cross\u2010sectional and observational study with a retrospective sample composed of participants hospitalised in the haematology clinic, who were diagnosed with haematological diseases. All participants received an oral mucosal examination and scraping from oral mucosa.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 62 participants, 56.5% were male and 82.3% were white, with mean age of 57\u2009years. Lymphoma was the most common haematological disease (24.2%). In total, 48.4% of the sample was diagnosed with oral candidiasis. Of the participants with oral candidiasis, 13 (21.0%) had a clinical diagnosis. Cytopathological analysis revealed 17 more (27.4%) cases without oral lesions indicative of candidiasis. Erythematous candidiasis (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.02), pseudomembranous candidiasis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), clinical candidiasis (<jats:italic>P<\/jats:italic>\u2009&lt;\u20090.001), fibrous hyperplasia (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.032), and coated tongue (<jats:italic>P<\/jats:italic>\u00a0=\u00a00.012) showed a correlation with a candidiasis cytopathological diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Oral candidiasis is common among patients with haematological disease, and the cytopathological examination proved to be a useful tool, confirming clinical diagnosis of candidiasis and identifying subclinical cases. These data are of great relevance considering the possible complications that these patients may develop, such as longer hospitalisations, worsening of the general condition or even death due to candidemia.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13151","type":"journal-article","created":{"date-parts":[[2022,5,23]],"date-time":"2022-05-23T07:50:22Z","timestamp":1653292222000},"page":"611-617","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Oral candidiasis in patients with haematological diseases: Diagnosis through clinical and cytopathological examinations"],"prefix":"10.1111","volume":"33","author":[{"given":"Fernanda Guimar\u00e3es de Azevedo","family":"Pereira","sequence":"first","affiliation":[{"name":"Postgraduate Program in Pathology, School of Medicine Universidade Federal Fluminense (UFF)  Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrianna","family":"Milagres","sequence":"additional","affiliation":[{"name":"Department of Pathology, School of Medicine Universidade Federal Fluminense (UFF)  Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana Trist\u00e3o","family":"Werneck","sequence":"additional","affiliation":[{"name":"Department of Specific Formation, School of Dentistry Universidade Federal Fluminense  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5701-6842","authenticated-orcid":false,"given":"Let\u00edcia C\u00f4go","family":"Marques","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pathology, School of Medicine Universidade Federal Fluminense (UFF)  Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruna Lavinas Sayed","family":"Picciani","sequence":"additional","affiliation":[{"name":"Department of Specific Formation, School of Dentistry Universidade Federal Fluminense  Rio de Janeiro Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arley Silva","family":"Junior","sequence":"additional","affiliation":[{"name":"Postgraduate Program in Pathology, School of Medicine Universidade Federal Fluminense (UFF)  Niter\u00f3i Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,6,24]]},"reference":[{"issue":"1","key":"e_1_2_10_2_1","first-page":"22","article-title":"Candid\u00edase","volume":"22","author":"Barbedo LS","year":"2010","journal-title":"J Bras Doen\u00e7as Sex Transm"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-64872-5_16"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof7020077"},{"issue":"2","key":"e_1_2_10_5_1","first-page":"114","article-title":"Identification of Candida spp. isolated from oral mucosa in patients with leukemias and lymphomas in Iran","volume":"11","author":"Hamzehee S","year":"2019","journal-title":"Iran J Microbiol"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12105-019-01004-6"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.18363\/rbo.v76.2019.e1412"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/20002297.2019.1601061"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1159\/000335063"},{"issue":"2","key":"e_1_2_10_10_1","first-page":"176","article-title":"Candid\u00edase oral em pacientes internados em UTI","volume":"71","author":"Siqueira JS","year":"2014","journal-title":"Rev Bras Odontol"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2010.00779.x"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/1735-3327.150339"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1590\/s1806-83242013000100018"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clindermatol.2016.02.022"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2012.11.033"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21551"},{"key":"e_1_2_10_17_1","volume-title":"Prorrogado Prazo Para Recebimento de Contribui\u00e7\u00f5es Sobre Dispositivos Eletr\u00f4nicos Para Fumar","author":"INCA \u2010 Instituto Nacional de C\u00e2ncer","year":"2021"},{"issue":"6","key":"e_1_2_10_18_1","first-page":"638","article-title":"Clinical analysis of 500 cases of hematological diseases with oral presentation as the first manifestation","volume":"29","author":"Dou HJ","year":"2020","journal-title":"Shanghai Kou Qiang Yi Xue"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.5892\/ruvrd.v13i2.2275"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.blre.2020.100738"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.idc.2019.01.001"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.4317\/jced.51242"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chom.2019.02.004"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2018.vol32.0092"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41579-018-0089-x"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.7476\/9788560035083"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijabmr.IJABMR_259_18"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1086\/313450"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjc.2011.450"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0714.2010.00937.x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1086\/520192"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.17796\/jcpd.34.3.y060151580h301t7"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02893420"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2012-02-387092"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13151","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.13151","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13151","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T19:25:43Z","timestamp":1692732343000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.13151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,6,24]]},"references-count":33,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2022,9]]}},"alternative-id":["10.1111\/cyt.13151"],"URL":"https:\/\/doi.org\/10.1111\/cyt.13151","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,6,24]]},"assertion":[{"value":"2022-03-15","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-05-17","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-06-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}