{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T15:46:21Z","timestamp":1772120781474,"version":"3.50.1"},"reference-count":46,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,7,26]],"date-time":"2022-07-26T00:00:00Z","timestamp":1658793600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Papillary thyroid carcinoma (PTC) is the most common primary malignant thyroid neoplasm and malignant diagnosis in thyroid aspirates. Metastatic adenocarcinoma of the lung is an under\u2010recognised mimicker which overlaps cytomorphologically and immunocytochemically with PTC. This case series reviews thyroid aspirates of metastatic lung carcinomas, aiming to address the similarities and methods of differentiating this entity from PTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Thyroid aspirates of metastatic lung carcinomas were obtained by a computerised search. Clinico\u2010cytological features and ancillary test results were reviewed. A literature review was performed for published cases of metastatic lung carcinomas in thyroid aspirates.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 14 cases were found, including nine adenocarcinomas, three TTF1\u2010positive non\u2010small cell lung carcinomas (NSCLCs), one small cell carcinoma and one squamous cell carcinoma. The adenocarcinomas and TTF1\u2010positive NSCLCs displayed PTC\u2010like features including papillae\/papillary\u2010like fronds (<jats:italic>n<\/jats:italic>\u00a0=\u00a06\/12, 50%), nuclear grooves (<jats:italic>n<\/jats:italic>\u00a0=\u00a05\/12, 41.7%) and inclusions (<jats:italic>n<\/jats:italic>\u00a0=\u00a01\/12, 8.3%), chromatin clearing (<jats:italic>n<\/jats:italic>\u00a0=\u00a03\/12, 25%), calcifications (<jats:italic>n<\/jats:italic>\u00a0=\u00a03\/12, 25%) and multinucleated giant cells (<jats:italic>n<\/jats:italic>\u00a0=\u00a02\/12, 16.7%). Useful distinguishing features observed were prominent nucleoli, coarse chromatin, mitosis, and necrosis. TTF\u20101 immunocytochemistry was positive in most cases (<jats:italic>n<\/jats:italic>\u00a0=\u00a05\/6, 83.3%), while PAX8 and thyroglobulin were consistently negative. <jats:italic>EGFR<\/jats:italic> exon 19 deletion was detected on cell block preparation in a single case, corresponding to its lung primary. The literature search yielded 84 cases of metastatic malignancies, with lung carcinomas comprising of 3.6%\u201333.3% in case series of metastatic malignancies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Metastatic adenocarcinoma of lung and PTC share significant cytomorphological and immunocytochemical similarities. A high degree of caution, meticulous clinico\u2010cytological assessment and prudent use of ancillary techniques is necessary to avoid potential misdiagnosis.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13164","type":"journal-article","created":{"date-parts":[[2022,7,9]],"date-time":"2022-07-09T09:44:29Z","timestamp":1657359869000},"page":"696-706","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Metastatic lung carcinoma in thyroid aspirates: A case series and literature review illustrating diagnostic challenges"],"prefix":"10.1111","volume":"33","author":[{"given":"Joanna Ka Man","family":"Ng","sequence":"first","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2425-0314","authenticated-orcid":false,"given":"Joshua Jing Xi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Anatomical and Cellular Pathology, Prince of Wales Hospital The Chinese University of Hong Kong  Shatin Hong Kong"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,7,26]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"Surgical Treatment: Evidence\u2010Based and Problem\u2010Oriented","author":"Gimm O","year":"2001"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.22955"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-60570-8_8"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/his.13348"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12501"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tcmj.2015.02.001"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21413"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.13110"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22559"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0500"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12940"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/1759-7714.13740"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.rmcr.2020.101065"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.5301\/TJ.5000605"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bcr-2016-217541"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23331"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23264"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.54.3742"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12022-015-9357-8"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13256-015-0707-4"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21494"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1097\/COC.0b013e31829d1d09"},{"issue":"2","key":"e_1_2_10_24_1","first-page":"E21","article-title":"Thyroid gland metastasis from small cell lung cancer: an unusual site of metastatic spread","volume":"5","author":"Katsenos S","year":"2013","journal-title":"J Thorac Dis"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0b013e31826cf59b"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2265.2007.02773.x"},{"issue":"1","key":"e_1_2_10_27_1","first-page":"51","article-title":"Metastasis to the thyroid gland; 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