{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T19:59:34Z","timestamp":1787774374968,"version":"build-2784847793"},"reference-count":27,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,9]],"date-time":"2022-09-09T00:00:00Z","timestamp":1662681600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The clinical performance of the Yokohama reporting system for breast cytology remains uncertain.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In this study, we retrospectively evaluated 318 breast fine needle aspirations (FNABs) from Los Angeles County Hospital over a five\u2010year period, analysing data for breast cytology, histology, and radiology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Among 318 breast FNAB cases, 78.3% (249\/318) were benign and 5.3% (17\/318) malignant. Of 83 cases with follow\u2010up histology, 14.5% (12\/83) were insufficient, 66.3% (55\/83) were benign, and 16.9% (17\/83) were malignant. Of 55 benign cases, 61.8% (34\/55) were fibroadenoma and 9 (9\/55, 16.4%) were fibrocystic changes. Two cases were diagnosed as \u201catypical\u201d but confirmed \u201cbenign\u201d on core needle biopsy (CNB). No \u201csuspicious\u201d cases were found. Seventeen malignant cases were confirmed by CNB, including 70.6% (12\/17) invasive ductal carcinoma, 11.8% (2\/17) invasive lobular carcinoma, and one malignant phyllodes tumour. Receptor studies on cell blocks of three malignant cases showed concordant results with CNB results. In addition, 82.2% (148\/180) of lesions with Breast Imaging\u2010Reporting and Data System (BI\u2010RADS) scores of 2 or 3 were benign and 92.3% (12\/13) BI\u2010RADS score 5 lesions were malignant on FNAB. Finally, 90% (67\/74) of BI\u2010RADS 4a lesions were benign, and 97% (36\/37) of fibroadenomas were BI\u2010RADS score 4a.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This, by far the largest U.S. breast cytology study, showed 93.3% sensitivity, 100% specificity, 100% positive predictive value, and 98.2% negative predictive value for breast FNAB. Women with breast lesions of BI\u2010RADS score 3 or less have a low risk of malignancy; FNAB would contribute to the reduction of excisional biopsies. FNAB can be considered as an initial diagnostic tool for BI\u2010RADS 4 mass\/lesions and satellite lesions, as well as for triaging patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13171","type":"journal-article","created":{"date-parts":[[2022,7,23]],"date-time":"2022-07-23T04:04:45Z","timestamp":1658549085000},"page":"707-715","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Performance of breast fine needle aspiration as an initial diagnostic tool: A large academic hospital experience"],"prefix":"10.1111","volume":"33","author":[{"given":"Zhengshan","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Southern California\/LAC\u2010USC Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Salibay","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Southern California\/LAC\u2010USC Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wafaa","family":"Elatre","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Southern California\/LAC\u2010USC Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wesley Y.","family":"Naritoku","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Southern California\/LAC\u2010USC Medical Center  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanling","family":"Ma","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of Southern California\/LAC\u2010USC Medical Center  Los Angeles California 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