{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T06:03:57Z","timestamp":1770271437697,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2022,9,5]],"date-time":"2022-09-05T00:00:00Z","timestamp":1662336000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2022,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Fine needle cytology (FNC) is widely used as a first\u2010line procedure in the diagnostic algorithm of lymphadenopathies. In a metastatic setting, a first\u2010line diagnostic approach identifies non\u2010haematopoietic malignancy; however, cytopathologists could also provide a second diagnostic level, identifying the origin of the primary tumour. This paper outlines a comprehensive and practical approach to the cytological diagnosis of lymph node metastases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cytological diagnoses of lymph node metastases performed over a 10\u2010year period were selected and divided into two groups. The first group, labelled \u201concological,\u201d comprised patients with a previous history of malignancy; the second group, labelled \u201cna\u00efve,\u201d included patients with no relevant history. Pathology records were retrieved to record microscopic findings, namely, background appearance, group architecture, and specific cell features; data from cell block (CB) preparations were also collected.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Overall, 982 cases were selected: 497 cases (50.61%) in the na\u00efve group, and 485 (49.39%) in the oncological group. Overall, a second diagnostic level was achieved in 834\/982 cases (84.92%); cases diagnosed as carcinoma not otherwise specified were more frequent in the na\u00efve group than in the oncological group (17.51% vs. 8.04%, <jats:italic>P<\/jats:italic>\u2009&lt;\u20090.01). Notably, although CB material was available in only 44.87% of the na\u00efve cases, we were able to achieve a second diagnostic level thanks to the integration of clinical and cytomorphological findings, plus lymph node topography, in 82.49% of the cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our results confirmed that in a metastatic setting, FNC can reliably lead to the identification of the origin of the primary tumour.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13172","type":"journal-article","created":{"date-parts":[[2022,8,20]],"date-time":"2022-08-20T12:59:57Z","timestamp":1661000397000},"page":"668-677","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A roadmap for a comprehensive diagnostic approach to fine needle cytology of lymph node metastases"],"prefix":"10.1111","volume":"33","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0803-0293","authenticated-orcid":false,"given":"Gennaro","family":"Acanfora","sequence":"first","affiliation":[{"name":"Department of Public Health University of Naples \"Federico II\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonino","family":"Iaccarino","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \"Federico II\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Dello Iacovo","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \"Federico II\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pasquale","family":"Pisapia","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \"Federico II\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6932-763X","authenticated-orcid":false,"given":"Caterina","family":"De Luca","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \"Federico II\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"Giordano","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Clinical Medicine and Surgery University of Naples \"Federico II\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7479-6457","authenticated-orcid":false,"given":"Claudio","family":"Bellevicine","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \"Federico II\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Picardi","sequence":"additional","affiliation":[{"name":"Hematology Section, Department of Clinical Medicine and Surgery University of Naples \"Federico II\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1630-5805","authenticated-orcid":false,"given":"Giancarlo","family":"Troncone","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \"Federico II\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Vigliar","sequence":"additional","affiliation":[{"name":"Department of Public Health University of Naples \"Federico II\"  Naples Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2022,9,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/aqaa191"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/CYT.13079"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNCY.22523"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.PRP.2020.153294"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506497"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI71606"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000478885"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/CNCY.22154"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/DC.24824"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24064"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1159\/000513149"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/TBJ.13402"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000493635"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/DC.24617"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/DC.24120"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/JCLINPATH-2020-206962"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1080\/17476348.2019.1646642"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/DC.24559"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP13307.OR"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13172","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.13172","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13172","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,22]],"date-time":"2023-08-22T05:30:06Z","timestamp":1692682206000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.13172"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,5]]},"references-count":19,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2022,11]]}},"alternative-id":["10.1111\/cyt.13172"],"URL":"https:\/\/doi.org\/10.1111\/cyt.13172","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,5]]},"assertion":[{"value":"2022-06-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-07-25","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2022-09-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}