{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T02:35:47Z","timestamp":1783132547044,"version":"3.54.6"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,1,5]],"date-time":"2023-01-05T00:00:00Z","timestamp":1672876800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2023,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Cervical cancer screening is as important in female\u2010to\u2010male transgender (FTMT) patients as it is in cisgender female patients. The aim of this study was to examine the impact of clinical information regarding gender identity and testosterone therapy on the cytological interpretations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A list of FTMT patients and cisgender female patients who had received a cervical Papanicolaou (Pap) test for cancer screening was obtained. The cytological diagnoses, rendered at the time of collection, were recorded. A retrospective slide review with knowledge of the pertinent clinical information, including testosterone therapy status, was performed. The data sets were statistically compared.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of 122 cervical Pap tests in 111 FTMT individuals, 23 (19%) had surgical follow\u2010ups; 73 (60%) had HPV testing, of which 12 (16%) were positive for high\u2010risk strains; and 79 (65%) were known to be receiving testosterone. On the \u201coriginal\u201d review, 12 (9.8%) tests were diagnosed as unsatisfactory. Seventy\u2010one (58%) Pap tests were initially diagnosed as negative for intraepithelial lesion or malignancy (NILM) without atrophy and 32 (26%) with atrophy. Seven (5.7%) of the tests were initially diagnosed as abnormal. On the \u201cretrospective\u201d review, the rate of unsatisfactory tests remained the same, and atrophy was observed in 76 (62%) tests. The number of abnormal tests was reduced to 4 (3.3%) after the retrospective review. Almost all comparative studies returned a <jats:italic>P<\/jats:italic>\u2010value of \u22640.05.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings indicate that clinical information regarding whether a subject is transgender and\/or is receiving testosterone therapy is crucial to avoiding Pap test overcalls.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13199","type":"journal-article","created":{"date-parts":[[2022,12,16]],"date-time":"2022-12-16T05:38:17Z","timestamp":1671169097000},"page":"120-129","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical history of <scp>female\u2010to\u2010male<\/scp> transgender patients is needed to avoid misinterpretation of <scp>cervical Papanicolaou<\/scp> tests"],"prefix":"10.1111","volume":"34","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9986-8058","authenticated-orcid":false,"given":"Neda 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USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika F.","family":"Rodriguez","sequence":"additional","affiliation":[{"name":"Department of Pathology &amp; Laboratory Medicine David Geffen School of Medicine at UCLA  Los Angeles California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,1,5]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.2105\/AJPH.2016.303571"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ps.202100306"},{"key":"e_1_2_9_4_1","volume-title":"How Many Adults and Youth Identify as Transgender in the United States?","author":"Herman 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