{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:25:32Z","timestamp":1784733932586,"version":"3.55.0"},"reference-count":18,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,3,8]],"date-time":"2023-03-08T00:00:00Z","timestamp":1678233600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2023,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objectives<\/jats:title><jats:p>Acinic cell carcinoma (AcCC) is often a challenging diagnosis on cytology. Recently, NOR\u20101 (NR4A3) has been demonstrated as a sensitive and specific marker for AcCC. Therefore, we conducted this study to evaluate NOR\u20101 expression in AcCC cytology specimens and to compare its reactivity in other salivary gland tumours (non\u2010AcCC).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively reviewed our database and selected cytology cases with available cell blocks, including 10 AcCC and 24 non\u2010AcCC tumours (12 benign tumours and 12 malignant tumours). NOR\u20101 (1:50 dilution; SC393902 [H\u20107]; Santa Cruz Biotech) immunohistochemistry (IHC) was performed on all cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All AcCC cases except two (2\/10, 80%) showed positive nuclear staining of variable intensity for NOR\u20101, with the majority of cases (75%) demonstrating at least moderately intense nuclear expression. All non\u2010AcCC cases were negative for NOR\u20101, demonstrating a specificity of 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We conclude that NOR\u20101 IHC is sensitive and very specific on cytology specimens and is able to distinguish AcCC from its mimickers reliably and classify them appropriately for further management.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13222","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T08:03:43Z","timestamp":1677225823000},"page":"219-224","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Diagnosis of acinic cell carcinoma of the salivary gland on cytology specimens: Role of NOR\u20101 (NR4A3) immunohistochemistry"],"prefix":"10.1111","volume":"34","author":[{"given":"Karleen","family":"Meiklejohn","sequence":"first","affiliation":[{"name":"Department of Pathology Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morgan","family":"Hrones","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Minhua","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manju L.","family":"Prasad","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8725-5940","authenticated-orcid":false,"given":"Guoping","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adebowale","family":"Adeniran","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6185-6062","authenticated-orcid":false,"given":"Syed M.","family":"Gilani","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale School of Medicine  New Haven Connecticut USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,3,8]]},"reference":[{"key":"e_1_2_10_2_1","volume-title":"WHO Classification of Tumours Editorial Board. 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