{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:50Z","timestamp":1747184270402,"version":"3.40.5"},"reference-count":13,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2023,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Haemoglobin spherulosis (HS) is a rare lesion occurring post\u2010vitreous haemorrhage that is absent from the cytopathology literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We present the fine needle aspiration (FNA) biopsy cytological features of a case of HS occurring in a 73\u2010year\u2010old woman.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>FNA smears of hemorrhagic vitreous fluid showed numerous variably sized smooth glassy spherules ranging from 3\u201020 \u03bcm. Occasional red cells and a rare lymphocyte were observed, but other cell types were absent. Immunohistochemical staining of a cell block showed diffuse positive staining of spherules with haemoglobin A.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>HS is a rare lesion that occurs post\u2010subretinal haemorrhage and may be encountered by pathologists examining ocular cytological specimens.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13223","type":"journal-article","created":{"date-parts":[[2023,2,24]],"date-time":"2023-02-24T13:55:29Z","timestamp":1677246929000},"page":"334-336","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Haemoglobin spherulosis: Fine needle aspiration biopsy of an unusual ocular lesion"],"prefix":"10.1111","volume":"34","author":[{"given":"Bindu S.","family":"Challa","sequence":"first","affiliation":[{"name":"Department of Pathology The Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0531-2690","authenticated-orcid":false,"suffix":"Jr","given":"Paul E.","family":"Wakely","sequence":"additional","affiliation":[{"name":"Department of Pathology The Ohio State University Wexner Medical Center, James Cancer Hospital and Solove Research Institute  Columbus Ohio USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1988.01060140107035"},{"key":"e_1_2_8_3_1","first-page":"85","article-title":"Intravitreal hemoglobin spherulosis: a rare complication of subretinal hemorrhage","volume":"120","author":"Schwartz SG","year":"2002","journal-title":"Arch Ophthalmol"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10792-011-9465-5"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/67.2.118"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/69.5.475"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0039-6257(97)84041-6"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000331286"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10236"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/2474126419880385"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1980.01020030728018"},{"volume-title":"StatPearls [Internet]","year":"2022","author":"Jena S","key":"e_1_2_8_12_1"},{"key":"e_1_2_8_13_1","first-page":"575","article-title":"Cell proliferation in response to vitreous hemoglobin","volume":"20","author":"Burke JM","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"e_1_2_8_14_1","first-page":"582","article-title":"Retinal proliferation in response to vitreous hemoglobin or iron","volume":"20","author":"Burke JM","year":"1981","journal-title":"Invest Ophthalmol Vis Sci"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13223","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.13223","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13223","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,19]],"date-time":"2023-08-19T05:59:35Z","timestamp":1692424775000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.13223"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,10]]},"references-count":13,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,7]]}},"alternative-id":["10.1111\/cyt.13223"],"URL":"https:\/\/doi.org\/10.1111\/cyt.13223","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"type":"print","value":"0956-5507"},{"type":"electronic","value":"1365-2303"}],"subject":[],"published":{"date-parts":[[2023,3,10]]},"assertion":[{"value":"2023-01-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-03-10","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}