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The HL molecular characterization still represents an ongoing challenge due to the low fraction of tumour Hodgkin and Reed\u2013Sternberg cells mixed with a plethora of non\u2010tumour haematological cells. In this scenario, next generation sequencing of liquid biopsy samples is emerging as a useful tool in HL patients' management. In this review, we aimed to overview the clinical and methodological topics regarding the implementation of molecular analysis in cHL, focusing on the role of liquid biopsy in diagnosis, follow\u2010up, and response prediction.<\/jats:p>","DOI":"10.1111\/cyt.13255","type":"journal-article","created":{"date-parts":[[2023,6,21]],"date-time":"2023-06-21T08:58:55Z","timestamp":1687337935000},"page":"182-187","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Liquid biopsy: A promising tool for driving strategies and predicting failures in patients with classic Hodgkin lymphoma"],"prefix":"10.1111","volume":"35","author":[{"given":"Francesco","family":"Pepe","sequence":"first","affiliation":[{"name":"Department of Public Health University of Naples Federico II  Naples 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