{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T00:57:55Z","timestamp":1747184275579,"version":"3.40.5"},"reference-count":30,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T00:00:00Z","timestamp":1687737600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2023,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Hepatocellular carcinoma (HCC) is a common primary malignancy of the liver but is rare in the paediatric age group; thus, it may be misdiagnosed as the more common tumour, hepatoblastoma. Management varies in both these tumours, and pathological diagnosis thus plays an important role for definitive therapy. Only a few case reports available in the literature have described the cytological characteristics of paediatric HCC. The present study was thus planned to evaluate the cytomorphological features of paediatric HCC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Cases diagnosed with HCC on ultrasound\u2010guided fine needle aspiration cytology over a period of 14\u2009years were retrieved. The cases were evaluated for detailed cytological features including cellularity, architecture, sinusoidal wrapping, trabecular thickness, necrosis, anisonucleosis, chromatin, nucleoli, nuclear contours, bi\u2010 or multinucleation, intranuclear and intracytoplasmic inclusions, naked nuclei, extra\u2010medullary haematopoiesis, monomorphism, and nuclear overlapping.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twelve cases of HCC were included in the study. The median age at diagnosis was 10\u2009years. Serum alpha\u2010fetoprotein level was raised in most of them. Five of the 12 cases were characterised as moderately differentiated, three as poorly differentiated, two as well differentiated, and two as the fibrolamellar type of HCC. Cytohistological correlation was performed in seven cases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Ultrasound\u2010guided fine needle aspiration serves as a useful tool to diagnose paediatric HCC and differentiate it from other primary hepatic malignancies, especially hepatoblastoma which closely mimics HCC in this age group, as serum alpha protein levels and imaging findings are unable to distinguish these two tumours.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13266","type":"journal-article","created":{"date-parts":[[2023,6,26]],"date-time":"2023-06-26T09:26:22Z","timestamp":1687771582000},"page":"479-488","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cytomorphology of paediatric hepatocellular carcinoma: A\u00a0useful diagnostic adjunct"],"prefix":"10.1111","volume":"34","author":[{"given":"Aasma","family":"Nalwa","sequence":"first","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  Jodhpur India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9907-7531","authenticated-orcid":false,"given":"Tripti","family":"Nakra","sequence":"additional","affiliation":[{"name":"Department of Pathology, University College of Medical Sciences University of Delhi  Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7597-4895","authenticated-orcid":false,"given":"Rajni","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ritika","family":"Walia","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep","family":"Agarwala","sequence":"additional","affiliation":[{"name":"Department of Paediatric Surgery All India Institute of Medical Sciences  New\u00a0Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manisha","family":"Jana","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5315-9814","authenticated-orcid":false,"given":"Deepali","family":"Jain","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Prasenjit","family":"Das","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sandeep R.","family":"Mathur","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Venkateswaran K.","family":"Iyer","sequence":"additional","affiliation":[{"name":"Department of Pathology All India Institute of Medical Sciences  New Delhi India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,6,26]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00268-005-7965-z"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3468(98)90005-7"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.2840040219"},{"key":"e_1_2_11_5_1","first-page":"235","volume-title":"Editorial Board. WHO Classification of Tumours Editorial Board. Digestive System Tumors","author":"Torbenson MS","year":"2019"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.2002.tb04090.x"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v9.i12.233"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/jhep.2003.50375"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1309\/TT0R7KAL32228E99"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S306963"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0676.2000.020002173.x"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2002.06.102"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jamcollsurg.2007.03.002"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1148\/rg.312105201"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cld.2015.01.010"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-013-0624-8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2011.00882.x"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1159\/000328523"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0272-2712(18)30160-4"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1186\/1477-7819-2-5"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.4103\/2278-330X.149949"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep4.1089"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22231"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23642"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34256"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.2013.80"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1159\/000367754"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14020272"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.117643"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1177\/10668969211050904"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.13100"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13266","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,16]],"date-time":"2023-08-16T19:17:33Z","timestamp":1692213453000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.13266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,6,26]]},"references-count":30,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,9]]}},"alternative-id":["10.1111\/cyt.13266"],"URL":"https:\/\/doi.org\/10.1111\/cyt.13266","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"type":"print","value":"0956-5507"},{"type":"electronic","value":"1365-2303"}],"subject":[],"published":{"date-parts":[[2023,6,26]]},"assertion":[{"value":"2022-11-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-09","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-06-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}