{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T03:43:10Z","timestamp":1773805390649,"version":"3.50.1"},"reference-count":38,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T00:00:00Z","timestamp":1696464000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2024,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The management of axillary lymph nodes in early\u2010stage breast cancer patients has changed considerably, with the primary focus shifting from the examination of sentinel lymph nodes (SLNs) to toward the detection of all macro\u2010metastases. However, current methods, such as touch imprint cytology (TIC) and frozen sections, are inadequate for clinical needs. To address this issue, we proposed a novel miniaturised epifluorescence widefield microscope (MEW\u2010M) to assess SLN status intraoperatively for improved diagnostic efficiency.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A prospective, side\u2010by\u2010side comparison of intraoperative SLN evaluation between MEW\u2010M and TIC was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 73 patients with 319 SLNs consecutive enrolled in this study. MEW\u2010M showed significantly superior image quality compared to TIC (median score 3.1 vs 2.1, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001) and had a shorter time to issue results (10.3 vs 19.4\u2009min, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.0001). Likelihood ratio analysis illustrated that the positive likelihood ratio value of MEW\u2010M compared with TIC was infinitely great vs 52.37 (95% CI, 21.96\u2010124.90) in model 1 (classifying results into negative\/positive), infinitely great vs 52.37 (95% CI, 21.96\u2010124.90) in model 2 (classifying results into macro\u2010metastasis\/others, and TIC results followed the same classification as model 1), respectively. Similarly, the negative likelihood ratio values of MEW\u2010M compared with TIC were 0.055 (95% CI, 0.018\u20100.160) and 0.074 (95% CI, 0.029\u20100.190) in model 1; and 0.019 (95% CI, 0.003\u20100.130) vs 0.020 (95% CI, 0.003\u20100.140) in model 2, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>MEW\u2010M is a promising technique that can be utilised to provide a rapid and accurate intraoperative assessment of SLN in a clinical setting to help improve decision\u2010making in axillary surgery.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13312","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T20:05:14Z","timestamp":1696536314000},"page":"136-144","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["A prospective comparison of a modified miniaturised hand\u2010held epifluorescence microscope and touch imprint cytology for evaluation of axillary sentinel lymph nodes intraoperatively in breast cancer patients"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9202-404X","authenticated-orcid":false,"given":"Jia\u2010jian","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Breast Surgery, Key Laboratory of Breast Cancer in Shanghai Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bao\u2010hua","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Pathology Fudan University Shanghai Cancer Center  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ti\u2010jing","family":"Shen","sequence":"additional","affiliation":[{"name":"Baoshan People's Hospital  Baoshan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ying","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Thyroid and Breast Surgery 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