{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T15:28:55Z","timestamp":1779377335140,"version":"3.53.1"},"reference-count":16,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2023,11,20]],"date-time":"2023-11-20T00:00:00Z","timestamp":1700438400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Interventional pathologists have expanded their expertise by acquiring proficiency in ultrasound\u2010guided thyroid fine\u2010needle aspiration biopsy (FNAB) and are now required to optimize punction procedures due to low resources and digital workflows. The aim of this study is to compare FNAB sample adequacy in two series with one versus two slides available for cytopathological analysis and its influence on diagnosis categorization, time taken to reach a final diagnosis, scanning time and size of the digital files produced.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients were retrospectively selected based on the sampling of thyroid nodules using either two glass slides (two\u2010slide group) or one slide only (one\u2010slide group) and cytological diagnosis was performed using the second edition of the Bethesda system. For each group, the initial 15 cases were sorted to be scanned.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From a total of 713 procedures, 328 were sampled into two slides and 385 on one slide only. No significant differences were found regarding nodule size, location or EU\u2010TIRADS classification between the two groups. The one\u2010slide group did not exhibit a higher prevalence of non\u2010diagnostic or atypia of undetermined significance (AUS) categories. As expected, the mean time taken to finalize diagnoses in cases where only one slide was prepared was 1.2\u2009days faster. Scanning time and total file size were also significantly smaller in the one\u2010slide group.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Adopting the \u2018one nodule\u2013one puncture\u2013one slide\u2019 strategy for thyroid FNAB optimization enhances procedural efficiency in digital workflows, leading to cost savings without compromising diagnostic accuracy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13338","type":"journal-article","created":{"date-parts":[[2023,11,21]],"date-time":"2023-11-21T11:26:23Z","timestamp":1700565983000},"page":"333-338","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["One nodule\u2013one punction\u2013one slide: Optimizing thyroid fine\u2010needle aspiration for a digital workflow"],"prefix":"10.1111","volume":"36","author":[{"given":"Ariana","family":"Maia","sequence":"first","affiliation":[{"name":"Endocrinology Department Centro Hospitalar Universit\u00e1rio de Santo Ant\u00f3nio  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B\u00e1rbara","family":"Carvalho","sequence":"additional","affiliation":[{"name":"Pathology Laboratory Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o","family":"Vale","sequence":"additional","affiliation":[{"name":"Pathology Laboratory Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP)  Porto Portugal"},{"name":"Department of Pathological Cytological and Tanathological Anatomy, School of Health of Polytechnic Institute of Porto (ESS | P.PORTO)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M\u00f3nica","family":"Curado","sequence":"additional","affiliation":[{"name":"Pathology Laboratory Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP)  Porto Portugal"},{"name":"Department of Pathological Cytological and Tanathological Anatomy, School of Health of Polytechnic Institute of Porto (ESS | P.PORTO)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmel","family":"Ryan","sequence":"additional","affiliation":[{"name":"Pathology Department St Marks Hospital  Harrow United Kingdom"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ant\u00f3nio","family":"Pol\u00f3nia","sequence":"additional","affiliation":[{"name":"Pathology Laboratory Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP)  Porto Portugal"},{"name":"Glycobiology in cancer, i3S\u2014Instituto de Investiga\u00e7\u00e3o e Inova\u00e7\u00e3o em Sa\u00fade  Porto Portugal"},{"name":"Departamento de sistemas biofuncionais do corpo humano da Escola de Medicina e Ci\u00eancias Biom\u00e9dicas Instituto de Investiga\u00e7\u00e3o, Inova\u00e7\u00e3o e Desenvolvimento, Funda\u00e7\u00e3o Fernando Pessoa (FP\u2010I3ID)  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7642-1280","authenticated-orcid":false,"given":"Catarina","family":"Eloy","sequence":"additional","affiliation":[{"name":"Pathology Laboratory Institute of Molecular Pathology and Immunology of University of Porto (IPATIMUP)  Porto Portugal"},{"name":"Pathology Department Medical Faculty of University of Porto  Porto Portugal"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,11,20]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-126-3-199702010-00009"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2016.0100"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoto.2014.1"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.4158\/EP.16.3.468"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000468519"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-28046-7"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2019.08.001"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00007611-199712000-00004"},{"issue":"3","key":"e_1_2_10_10_1","first-page":"353","article-title":"Comparison of conventional smear and liquid\u2010based cytology in adequacy of thyroid fine\u2010needle aspiration biopsies without an accompanying Cytopathologist","volume":"56","author":"Sayer AO","year":"2022","journal-title":"Sisli Etfal Hastan Tip Bul"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000504094"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24996"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23544"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12243"},{"issue":"2","key":"e_1_2_10_15_1","first-page":"73","article-title":"Interventional pathology: one small step for the pathologist, one big leap for the speciality","volume":"55","author":"Nieto Llanos S","year":"2022","journal-title":"Rev Esp Patol"},{"issue":"1","key":"e_1_2_10_16_1","first-page":"93","article-title":"Evaluation of thyroid fine\u2010needle aspiration biopsies according to cytological methods and comparison with histopathological diagnosis","volume":"55","author":"Ucak R","year":"2021","journal-title":"Sisli Etfal Hastan Tip Bul"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12806"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13338","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,6,10]],"date-time":"2025-06-10T07:46:57Z","timestamp":1749541617000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.13338"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11,20]]},"references-count":16,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1111\/cyt.13338"],"URL":"https:\/\/doi.org\/10.1111\/cyt.13338","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,11,20]]},"assertion":[{"value":"2023-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-09","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}