{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T13:22:39Z","timestamp":1769520159985,"version":"3.49.0"},"reference-count":74,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T00:00:00Z","timestamp":1701734400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>The Yokohama System for Reporting Endometrial Cytology (TYS) has been proposed by an expert meeting under the auspices of the International Academy of Cytology (IAC) in May 2016 at the IAC in Yokohama. Since its introduction, the TYS has been receiving worldwide acceptance, and this review aims to assess its global impact. The adoption of endometrial cytology as a diagnostic procedure has been hampered in the past by difficulties arising in interpreting the cellular findings due to a number of factors (such as excess blood, cellular overlapping and the complex physiology of endometrium). Recently, the use of liquid\u2010based cytology (LBC), with its ability to remove blood and mucus and to distribute cells uniformly in a thin layer on the slide, has provided an opportunity to re\u2010evaluate the role of endometrial cytology. LBC is a useful tool in the cytologic diagnosis and follow\u2010up of endometrial abnormalities, which remains complementary to the emerging molecular diagnostic cytopathology. The study of LBC from endometrial cytology could be challenging since it is affected by numerous look\u2010alikes and diagnostic pitfalls. This review discusses these various entities and takes into consideration the ancillary techniques that may be useful in the diagnostic procedure. In conclusion, our review of the published data suggests that the TYS is a valid classification scheme that has been widely accepted by cytopathologists globally, is highly reproducible and makes a valuable contribution to clinical therapeutic management. At present, molecular cytopathology is a rapidly evolving field of modern cytopathology, which underlines the effective interplay between genomics and cytology. This review aims to provide a comprehensive review of the drawbacks of endometrial cytopathology, particularly in terms of endometrial cancer diagnosis and molecular testing.<\/jats:p>","DOI":"10.1111\/cyt.13342","type":"journal-article","created":{"date-parts":[[2023,12,5]],"date-time":"2023-12-05T09:32:13Z","timestamp":1701768733000},"page":"350-361","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["A review of the directly sampled endometrial cytology on <scp>LBC<\/scp> samples: Classification, microscopic criteria and beyond"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5733-906X","authenticated-orcid":false,"given":"Yoshiaki","family":"Norimatsu","sequence":"first","affiliation":[{"name":"Departments of Medical Technology, Faculty of Health Sciences Ehime Prefectural University of Health Sciences  Iyo\u2010gun Ehime Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0051-0075","authenticated-orcid":false,"given":"Yoshinobu","family":"Maeda","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Toyama Red Cross Hospital  Toyama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1719-293X","authenticated-orcid":false,"given":"Natalia","family":"Malara","sequence":"additional","affiliation":[{"name":"Department of Health Sciences University Magna Graecia  Catanzaro Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4244-1109","authenticated-orcid":false,"given":"Franco","family":"Fulciniti","sequence":"additional","affiliation":[{"name":"Department of Pathology Unilabs Switzerland SA  Basel Switzerland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8557-9207","authenticated-orcid":false,"given":"Tadao K.","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Educational Institution Tenri University, Member of the Board  Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2023,12,5]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23916"},{"key":"e_1_2_11_3_1","first-page":"297","article-title":"Criteria for the cytologic assessment of hyperplasia in endometrial samples obtained by the Endopap endometrial sampler","volume":"29","author":"Meisels A","year":"1985","journal-title":"Acta Cytol"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.38.5.502"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21734"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1136\/jcp.39.1.36"},{"key":"e_1_2_11_7_1","first-page":"373","article-title":"Endocyte endometrial smears in the cytodiagnosis of endometrial carcinoma","volume":"34","author":"Byren AJ","year":"1990","journal-title":"Acta Cytol"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000332794"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-3154-0.00026-0"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.5795\/jjscc.37.650"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.5795\/jjscc.49.297"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-46334-6_7"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.anndiagpath.2007.05.005"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1159\/000353148"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502108"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5011-6_8"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5011-6_9"},{"key":"e_1_2_11_18_1","first-page":"125","volume-title":"WHO Classification of Tumour of Female Reproductive Organs","author":"Zaino R","year":"2014"},{"key":"e_1_2_11_19_1","first-page":"248","volume-title":"WHO Classification of Tumour of Female Reproductive Organs","author":"Ellenson LH","year":"2020"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-46334-6_8"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5011-6_10"},{"key":"e_1_2_11_22_1","first-page":"250","volume-title":"WHO Classification of Tumour of Female Reproductive Organs","author":"Ellenson LH","year":"2020"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5011-6_11"},{"key":"e_1_2_11_24_1","first-page":"252","volume-title":"WHO Classification of Tumour of Female Reproductive Organs","author":"Bosse T","year":"2020"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-46334-6_9"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(83)90111-7"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(13)70591-6"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature12113"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2303.2008.00589.x"},{"key":"e_1_2_11_30_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21784"},{"key":"e_1_2_11_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12902"},{"key":"e_1_2_11_32_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-199712000-00015"},{"key":"e_1_2_11_33_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200006000-00004"},{"key":"e_1_2_11_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800271"},{"key":"e_1_2_11_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318202772e"},{"key":"e_1_2_11_36_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5011-6_12"},{"key":"e_1_2_11_37_1","first-page":"236","article-title":"Histopathological findings of the endometrium in patients with dysfunctional uterine bleeding","volume":"23","author":"Vakiani M","year":"1996","journal-title":"Clin Exp Obstet Gynecol"},{"key":"e_1_2_11_38_1","doi-asserted-by":"publisher","DOI":"10.1093\/humupd\/8.1.60"},{"key":"e_1_2_11_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0378-5122(03)00068-9"},{"key":"e_1_2_11_40_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20524"},{"key":"e_1_2_11_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21141"},{"key":"e_1_2_11_42_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.21738"},{"key":"e_1_2_11_43_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-198012000-00004"},{"key":"e_1_2_11_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/99.6.741"},{"key":"e_1_2_11_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200111000-00001"},{"key":"e_1_2_11_46_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20512"},{"key":"e_1_2_11_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2559.2001.01215.x"},{"key":"e_1_2_11_48_1","doi-asserted-by":"publisher","DOI":"10.1097\/01.pgp.0000130051.04396.13"},{"key":"e_1_2_11_49_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200204000-00001"},{"key":"e_1_2_11_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.13070"},{"key":"e_1_2_11_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800960"},{"key":"e_1_2_11_52_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e3181483ff8"},{"key":"e_1_2_11_53_1","doi-asserted-by":"publisher","DOI":"10.1309\/AJCPQDQXJ4FNRFQB"},{"key":"e_1_2_11_54_1","doi-asserted-by":"publisher","DOI":"10.1097\/PGP.0b013e3181cd6552"},{"key":"e_1_2_11_55_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12677"},{"key":"e_1_2_11_56_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20655"},{"key":"e_1_2_11_57_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.32514"},{"key":"e_1_2_11_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13148-020-00958-7"},{"key":"e_1_2_11_59_1","doi-asserted-by":"publisher","DOI":"10.1111\/tog.12722"},{"key":"e_1_2_11_60_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179299X19830977"},{"key":"e_1_2_11_61_1","doi-asserted-by":"publisher","DOI":"10.1038\/s4167-021-21257-6"},{"key":"e_1_2_11_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.559016"},{"key":"e_1_2_11_63_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen-2021-050755"},{"key":"e_1_2_11_64_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24906"},{"key":"e_1_2_11_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5011-6_14"},{"key":"e_1_2_11_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2014.06.031"},{"key":"e_1_2_11_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.154019"},{"key":"e_1_2_11_68_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14215429"},{"issue":"14","key":"e_1_2_11_69_1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214318","article-title":"Phenotype of POLE\u2010mutated endometrial cancer","volume":"27","author":"Imboden S","year":"2019","journal-title":"PLoS One"},{"key":"e_1_2_11_70_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.20.00549"},{"key":"e_1_2_11_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5011-6_15"},{"key":"e_1_2_11_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5011-6_16"},{"key":"e_1_2_11_73_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5011-6_18"},{"key":"e_1_2_11_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pmed.1002206"},{"key":"e_1_2_11_75_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2015.61.3083"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,4,8]],"date-time":"2024-04-08T04:18:52Z","timestamp":1712549932000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.13342"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,5]]},"references-count":74,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2024,5]]}},"alternative-id":["10.1111\/cyt.13342"],"URL":"https:\/\/doi.org\/10.1111\/cyt.13342","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,5]]},"assertion":[{"value":"2023-10-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-12","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}