{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,29]],"date-time":"2026-08-29T07:12:26Z","timestamp":1787987546294,"version":"build-2784847793"},"reference-count":16,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T00:00:00Z","timestamp":1701820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>EBUS\u2010TBNA is a method of acquiring tissue samples from intrathoracic lymph nodes and central intrathoracic tumours in patients suspected of having lung cancer. Rapid on\u2010site evaluation (ROSE) denotes assessing tissue samples during EBUS (or bronchoscopy), providing instant feedback on sample adequacy and provisional cytomorphological diagnosis. Sector multidisciplinary team (MDT) discussion can then make informed treatment decisions, with confirmatory immunohistochemistry being finalised before provision of final treatment. Currently, impact of ROSE on length of time patients spend on the lung cancer diagnostic pathway remains unclear.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We retrospectively evaluated the impact of ROSE on the length of time between patients' EBUS\/bronchoscopy procedures and discussion at sector MDT, referred to as time to treatment decision (TTD), at our institution. Additionally, we assessed impact of ROSE on number of passes (number of times nodes\/masses were sampled) per procedure.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean TTD was 77.9% shorter (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) with ROSE present than when absent. Patients who received ROSE spend 34.3% less time (<jats:italic>p<\/jats:italic>\u2009=\u20090.028) on lung cancer diagnostic pathway overall. There was a significant reduction in number of passes in non\u2010malignant nodes with ROSE present (2.23) than when absent (3.14) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). With ROSE present there was a significantly greater number of passes at malignant sites (5.07) than non\u2010malignant sites (2.23) (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings support conclusions made in our institution's previous study, that utilisation of ROSE reduces TTD. ROSE also allows safe advancement through nodes with low suspicion of malignant involvement, focusing time on sampling nodes\/masses of greater suspicion.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13345","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T17:28:24Z","timestamp":1701883704000},"page":"250-255","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Impact of rapid on\u2010site evaluation in expediting the fast investigative lung cancer pathway"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-8945-5768","authenticated-orcid":false,"given":"Andrew","family":"Fowell","sequence":"first","affiliation":[{"name":"Department of Respiratory Medicine Manchester Royal Infirmary  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kashif","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Respiratory Medicine Manchester Royal Infirmary  Manchester UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,6]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.4103\/JOC.JOC_172_18"},{"key":"e_1_2_10_3_1","first-page":"2851","article-title":"Concordance between rapid on\u2010site cytology evaluation (ROSE) and final diagnosis in patients undergoing Endobronchial ultrasound\u2010 guided Transbronchial needle aspiration (EBUS\u2010TBNA)","volume":"56","author":"Khan KA","year":"2020","journal-title":"Eur Respir J"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.13204"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12328"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.25011"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2011-200713"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmed.2019-0218"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/LBR.0000000000000274"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1378\/chest.15-1216"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lungcan.2022.01.018"},{"key":"e_1_2_10_12_1","first-page":"A1","article-title":"P71\u2009impact of national optimal lung cancer pathway \u2013 can we meet the 28 day standard by 2020?","volume":"73","author":"Kutubudin F","year":"2018","journal-title":"Thorax"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2021-216865"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12032\u2010019\u20101271\u20103"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-319-40389-2_14"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201311-2007CI"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjresp-2020-000777"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.13345","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,7]],"date-time":"2024-02-07T10:02:54Z","timestamp":1707300174000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.13345"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,6]]},"references-count":16,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/cyt.13345"],"URL":"https:\/\/doi.org\/10.1111\/cyt.13345","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,6]]},"assertion":[{"value":"2023-08-17","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-11-22","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-06","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}