{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T23:31:29Z","timestamp":1777419089836,"version":"3.51.4"},"reference-count":62,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,1,11]],"date-time":"2024-01-11T00:00:00Z","timestamp":1704931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recognizing the parathyroid gland and distinguishing the parathyroid from thyroid lesions in fine needle aspiration (FNA) is challenging. This study aimed to identify cytomorphologic features suggestive of parathyroid origin and to assess the utility of cytopathology in conjunction with ancillary tests in the identification of parathyroid glands.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and methods<\/jats:title><jats:p>Ultrasound (US) guided FNA of parathyroid gland and lesions in 81 patients were reviewed concerning clinical history and correlated to histopathologic findings in available cases. FNA smears were evaluated for cellularity, architectural patterns, cellular and nuclear features, and background of the smears. In 78 cases, FNA was supplemented by a measurement of parathormone (PTH) levels in the needle washout fluid (FNA\u2010PTH assay) and\/or GATA3\/PTH\/chromogranin\u2010A immunostainings.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty\u2010four cases were diagnosed cytologically as parathyroid lesions in conjunction with FNA\u2010PTH assay and\/or immunocytochemical examinations. In an additional nine cases, a diagnosis of parathyroid lesions was rendered after repeated FNA with FNA\u2010PTH assay. The histolopathologic diagnosis of surgically excised cases (<jats:italic>n<\/jats:italic>\u2009=\u200975) included parathyroid adenoma (60 cases), atypical parathyroid adenoma (4 cases), parathyroid hyperplasia (10 cases), and parathyroid carcinoma (1 case). Major cytological findings of parathyroid tissue included high cellularity, scattered naked nuclei, cribriform and three\u2010dimensional clusters, stippled chromatin, and oxyphilic cytoplasm while papillary pattern or colloid\u2010like material was identified in three cases respectively. No nuclear grooves or inclusions were seen in any case.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>High cellularity scattered naked nuclei, cribriform and three\u2010dimensional patterns, stippled chromatin and oxyphilic cytoplasm are cytomorphologic features that favour parathyroid origin. A combination of these features with FNA\u2010PTH assay and\/or GATA3, PTH, and chromogranin\u2010A immunostainings on cytologic specimens aid in the identification of parathyroid glands and the distinguishing of parathyroid from thyroid lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13356","type":"journal-article","created":{"date-parts":[[2024,1,12]],"date-time":"2024-01-12T07:44:48Z","timestamp":1705045488000},"page":"362-370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Fine needle aspiration biopsy of parathyroid; is it meaningful? A cytologic study of 81 cases with histological and clinical correlations"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3001-0421","authenticated-orcid":false,"given":"Elwira","family":"Baku\u0142a\u2010Zalewska","sequence":"first","affiliation":[{"name":"Department of Pathology and Laboratory Diagnostics Maria Sklodowska\u2010Curie National Research Institute of Oncology (MSCNRIO)  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joanna","family":"D\u0142ugosi\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Oncological Endocrinology and Nuclear Medicine Maria Sklodowska\u2010Curie National Research Institute of Oncology (MSCNRIO)  Warsaw Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agata","family":"Stanek\u2010Widera","sequence":"additional","affiliation":[{"name":"Medical University of Silesia  Katowice 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