{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:47:47Z","timestamp":1787014067518,"version":"build-2736575974"},"reference-count":21,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T00:00:00Z","timestamp":1707782400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008459","name":"University of Calgary","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008459","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Molecular subtyping of non\u2010small cell lung cancer (NSCLC) is critical in the diagnostic evaluation of patients with advanced disease. This study aimed to examine whether samples from endobronchial ultrasound transbronchial needle aspiration (EBUS\u2010TBNA) of intrathoracic lymph nodes and\/or lung lesions are adequate for molecular analysis across various institutions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively reviewed all cases of linear EBUS\u2010TBNA with a final bronchoscopic diagnosis of NSCLC entered in the Stather Canadian Outcomes registry for chest ProcEdures database. The primary outcome was specimen inadequacy rate for each molecular target, as defined by the local laboratory or pathologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 866 EBUS\u2010TBNA procedures for NSCLC were identified. Specimen inadequacy rates were 3.8% for EGFR, 2.5% for ALK\u20101 and 3.5% for PD\u2010L1. Largest target size was not different between adequate and inadequate specimens, and rapid onsite evaluation did not increase specimen adequacy rates. One centre using next\u2010generation sequencing for EGFR had lower adequacy rates than 2 others using matrix\u2010assisted laser desorption\/ionization time\u2010of\u2010flight mass spectrophotometry.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>EBUS\u2010TBNA specimens have a very low\u2010specimen inadequacy rate for molecular subtyping of non\u2010small cell lung cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cyt.13367","type":"journal-article","created":{"date-parts":[[2024,2,13]],"date-time":"2024-02-13T09:40:00Z","timestamp":1707817200000},"page":"378-382","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Molecular analysis of endobronchial ultrasound needle aspirates in patients with non\u2010small cell lung cancer: Results from the SCOPE database"],"prefix":"10.1111","volume":"35","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2590-882X","authenticated-orcid":false,"given":"Erik","family":"Vakil","sequence":"first","affiliation":[{"name":"Division of Respirology University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elaine","family":"Dumoulin","sequence":"additional","affiliation":[{"name":"Division of Respirology University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Stollery","sequence":"additional","affiliation":[{"name":"Division of Critical Care Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashley\u2010Mae","family":"Gillson","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"MacEachern","sequence":"additional","affiliation":[{"name":"Division of Respirology University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Inderdeep","family":"Dhaliwal","sequence":"additional","affiliation":[{"name":"Division of Respirology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Mitchell","sequence":"additional","affiliation":[{"name":"Division of Respirology Western University  London Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pen","family":"Li","sequence":"additional","affiliation":[{"name":"Division of Pulmonary Medicine University of Alberta  Edmonton Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin","family":"Schieman","sequence":"additional","affiliation":[{"name":"Section of Thoracic Surgery University of Calgary  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Romatowski","sequence":"additional","affiliation":[{"name":"Division of Respirology Alberta Health Services  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex C.","family":"Chee","sequence":"additional","affiliation":[{"name":"Division of Respirology Alberta Health Services  Calgary Alberta Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung Chun","family":"Tyan","sequence":"additional","affiliation":[{"name":"Division of Respirology, Critical Care and Sleep Medicine University of Saskatchewan  Saskatoon Saskatchewan Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc","family":"Fortin","sequence":"additional","affiliation":[{"name":"Department of Medicine Universit\u00e9 Laval  Quebec City Quebec 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endobronchial ultrasound\u2010guided transbronchial needle aspiration samples for programmed death ligand\u20101 testing in non\u2010small cell lung cancer, the Bristol experience","volume":"18","author":"Hardy J","year":"2021","journal-title":"Asia Pac J Clin 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