{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,24]],"date-time":"2025-03-24T04:11:38Z","timestamp":1742789498013,"version":"3.40.2"},"reference-count":39,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T00:00:00Z","timestamp":1733702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100009780","name":"Region Sk\u00e5ne","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100009780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Fine\u2010needle aspiration cytology (FNAC) from bone lesions has been proven to be a useful diagnostic tool but lacks standardisation. The aim of the study was to evaluate the diagnostic utility of FNAC as a basis to propose and test a reporting system for bone reporting cytopathology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This retrospective study is based on patients with bone lesions, that were approached by cytology at Sk\u00e5ne University Hospital, Sweden between 2015 and 2023. The diagnostic performance was measured by sensitivity, specificity and accuracy analyses. All diagnoses were then distributed in six categories: (I) Non\u2010diagnostic, (II) Benign, (III) Atypia, (IV) Bone neoplasm of uncertain significance, (V) Suspicious for malignancy and (VI) Malignant. The risk of malignancy (ROM) in each category was calculated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The final cohort consisted of 721 cases. Bone cytology was able to differentiate between benign and malignant lesion with a sensitivity of 89% and a specificity of 99%. The overall diagnostic accuracy was 65% but varied significantly among different types of lesions. Within the tested diagnostic categories, the ROM was (I) 48%, (II) 6.7%, (III) 69%, (IV) 28%, (V) 93% and (VI) 100%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>FNAC from bone lesions is a sensitive and specific diagnostic tool with high diagnostic accuracy among various tumour types. This study provides valuable insights for the development of a standardised reporting system for bone cytopathology.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13462","type":"journal-article","created":{"date-parts":[[2024,12,9]],"date-time":"2024-12-09T12:45:54Z","timestamp":1733748354000},"page":"123-139","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Reporting Bone Cytopathology\u2014A Proposal Based on a Single Tertiary Centre Experience"],"prefix":"10.1111","volume":"36","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0886-2794","authenticated-orcid":false,"given":"Jan","family":"K\u00f6ster","sequence":"first","affiliation":[{"name":"Division of Clinical Genetics, Department of Laboratory Medicine Lund University  Lund Sweden"},{"name":"Department of Clinical Genetics, Pathology and Molecular Diagnostic Division of Laboratory Medicine  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5698-6281","authenticated-orcid":false,"given":"Camila Bedeschi Rego","family":"De Mattos","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, Department of Clinical Science Lund Sk\u00e5ne University Hospital  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0084-9499","authenticated-orcid":false,"given":"Henryk A.","family":"Domanski","sequence":"additional","affiliation":[{"name":"Department of Clinical Genetics, Pathology and Molecular Diagnostic Division of Laboratory Medicine  Lund Sweden"},{"name":"Department of Clinical Sciences, Division of Pathology Lund University  Lund Sweden"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,12,9]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12914"},{"key":"e_1_2_11_3_1","first-page":"6486","article-title":"Fine Needle Aspiration Cytology in Pediatric Tumors: A Low\u2010Cost, High\u2010Accuracy Diagnostic Tool for Resource\u2010Limited Settings","volume":"15","author":"Gupta P.","year":"2023","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.path.2011.07008"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.21154"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/J.ANNDIAGPATH.2022.151936"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10196"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20988"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20240"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23807"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/S41374\u2010022\u201000770\u20102"},{"volume-title":"Soft Tissue and Bone Tumours","year":"2020","author":"WHO Classification of Tumours Editorial Board","key":"e_1_2_11_12_1"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.21105\/joss.01686"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.32614\/RJ-2021-053"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1159\/000325833"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000511259"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000225)90:1<47::AID-CNCR7>3.0.CO;2-T"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2020.05.012"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.13270"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.jcrt_1381_22"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1097\u20100142(19970625)81:3<148::aid\u2010cncr4>3.0.co;2\u2010n"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.10265"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jasc.2022.09.005"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1159\/000339196"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20562"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097\u20100142(19880915)62:6<1238::aid\u2010cncr2820620632>3.0.co;2\u2010l"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.4103\/0970\u20109371.160573"},{"key":"e_1_2_11_28_1","doi-asserted-by":"publisher","DOI":"10.4103\/1742\u20106413.62257"},{"key":"e_1_2_11_29_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20436"},{"key":"e_1_2_11_30_1","first-page":"863","article-title":"Fine Needle Aspiration Biopsy Diagnosis of Giant\u2010Cell Tumor of Bone. 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