{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,11]],"date-time":"2025-04-11T04:02:47Z","timestamp":1744344167004,"version":"3.40.4"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T00:00:00Z","timestamp":1737590400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Traditional teaching dictated that patients with recurrent thyroid cysts undergo excision owing to a 12% risk malignancy. Ultrasound evaluation now determines management of these patients augmented by fine needle biopsy. In UK, a non\u2010diagnostic category for thyroid cysts (Thy1c) exists, whereas the Bethesda system combines \u2018non\u2010diagnostic\u2014cyst fluid only\u2019 into Category I along with paucicellular and acellular results. The aim was to assess the ability of Thy1c cytology to exclude malignancy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We undertook a retrospective study of patients undergoing thyroidectomy with Thy1c cytology from analysis of the Unit database. Additionally, we made a retrospective search in our pathology database for reports combining \u2018papillary thyroid carcinoma\u2019 with \u2018cyst\u2019 or \u2018cystic\u2019 and compared histology with cytology.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Between 2003 and 2023 115 patients (97 women, median age 44y, range 16\u201372) underwent thyroidectomy following Thy1c cytology. Indications for surgery included recurrent cyst (90%); compressive symptoms (9%) and one thyrotoxicosis. In no patient was the primary diagnosis malignant; multinodular goitre was commonest (87.76%); benign cyst (19.16%); follicular adenoma (5.4%) and coincidental pT1a classical papillary thyroid carcinoma (PTC) (4.3%). In the retrospective audit, 61 pathology reports contained \u2018PTC\u2019 and \u2018cyst\u2019\/\u2018cystic\u2019. The cystic element was in primary tumour (31.51%); nodal metastasis (17.28%) and adjacent benign disease (13.21%). Only 5 (8%) patients had Thy1c cytology; 4 had pT1a tumours and one a benign cyst and a 19\u2009mm PTC.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Thy1c category reliably excludes significant malignancy. For patients with symptomatic cysts, ultrasound assessment and Thy1c cytology can guide the clinician to treat with either ablation or resection without the fear of mistreating a thyroid cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13471","type":"journal-article","created":{"date-parts":[[2025,1,23]],"date-time":"2025-01-23T14:30:17Z","timestamp":1737642617000},"page":"236-239","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Thy1c Cytology Is a Reliable Method of Excluding Thyroid Cancer in Dominant Cystic Nodules"],"prefix":"10.1111","volume":"36","author":[{"given":"A.","family":"Regan","sequence":"first","affiliation":[{"name":"Department of Endocrine Surgery University Hospital of Wales  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.","family":"Boyd","sequence":"additional","affiliation":[{"name":"Cellular Pathology University Hospital of Wales  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery University Hospital of Wales  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"M. J.","family":"Stechman","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery University Hospital of Wales  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9040-023X","authenticated-orcid":false,"given":"D.","family":"Scott\u2010Coombes","sequence":"additional","affiliation":[{"name":"Department of Endocrine Surgery University Hospital of Wales  Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,23]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.5005\/jp\/books\/12798"},{"volume-title":"The New Aird's Companion in Surgical Studies","year":"2005","author":"Burnand K. 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