{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T04:47:07Z","timestamp":1775018827739,"version":"3.50.1"},"reference-count":30,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T00:00:00Z","timestamp":1738108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>An accurate fine\u2010needle aspiration (FNA) diagnosis of adrenal lesions may be challenging. This study was to investigate roles of imaging guidance, rapid on\u2010site evaluation (ROSE) and additional tissue sampling in FNA diagnosis of adrenal lesions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Adrenal FNA cases were retrieved from pathology archive. Patients' demographics, lesion size and location, imaging guidance methods, cytologic diagnoses and histopathologic diagnoses were reviewed and analysed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study cohort included 72 cases of left (86%) and right (14%) adrenal lesions. Endoscopic ultrasound (EUS) and computed tomography (CT) were used in 47 (65%) and 25 (35%) cases, respectively. Left adrenal lesions were sampled mostly by EUS\u2010FNA (73%), whereas right adrenal lesions by CT\u2010guided FNA (80%). There were no differences between the EUS\u2010FNA and CT\u2010FNA groups in terms of non\u2010diagnostic rate and cytologic diagnostic categories. The non\u2010diagnostic rate and cytologic diagnostic categories were the same between ROSE and non\u2010ROSE groups. In a subset of 18 cases with concurrent core tissue biopsy, a definite diagnosis was rendered in all biopsy cases including three cases with a non\u2010diagnostic or indeterminate cytology diagnosis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrates that FNA has great efficacy for evaluation of adrenal lesions, either via EUS or CT guidance. Incorporation of ROSE evaluation into FNA procedure does not directly affect the performance of FNA biopsy but may help direct additional tissue sampling to salvage the cases with a non\u2010diagnostic or indeterminate cytology diagnosis, increasing diagnostic yield.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13472","type":"journal-article","created":{"date-parts":[[2025,1,29]],"date-time":"2025-01-29T13:28:15Z","timestamp":1738157295000},"page":"228-235","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Fine\u2010Needle Aspiration Biopsy of Adrenal Gland Lesions: The Roles of Image Guidance, Rapid On\u2010Site Evaluation and Additional Tissue Sampling"],"prefix":"10.1111","volume":"36","author":[{"given":"Sanhong","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Pathology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Darin","family":"Dolezal","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Harry R.","family":"Aslanian","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, Section of Digestive Disease Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8725-5940","authenticated-orcid":false,"given":"Guoping","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Pathology Yale University School of Medicine  New Haven Connecticut USA"},{"name":"Yale Cancer Center Yale University School of Medicine  New Haven Connecticut USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,1,29]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.13395"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(19840801)54:3<552::AID-CNCR2820540328>3.0.CO;2-R"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-19-0263"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.2214\/AJR.07.2799"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1210\/endrev\/bnaa008"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-90684-9_10"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2010.10.018"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.24261"},{"issue":"3","key":"e_1_2_10_10_1","first-page":"307","article-title":"Endoscopic Ultrasound\u2010Guided Fine\u2010Needle Aspiration in the Diagnosis of Adrenal Lesions","volume":"29","author":"Patil R.","year":"2016","journal-title":"Annals of Gastroenterology"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-1004322"},{"issue":"3","key":"e_1_2_10_12_1","first-page":"173","article-title":"Transduodenal EUS\u2010Guided FNA of the Right Adrenal Gland to Diagnose Lung Cancer Where Percutaneous Approach Was Not Possible","volume":"59","author":"Eloubeidi M. 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