{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,26]],"date-time":"2026-07-26T02:48:59Z","timestamp":1785034139476,"version":"3.55.0"},"reference-count":23,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T00:00:00Z","timestamp":1743033600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Management of axillary lymph nodes (ALNs) in breast cancer patients remains pivotal for staging and planning therapeutic strategies. However, In low\u2010resource settings, achieving accurate axillary staging while avoiding overtreatment remains a challenge as the majority of patients present with advanced stage. In this prospective validation study, we assessed the efficacy of axillary ultrasound (AUS) combined with touch imprint cytology (TIC) for predicting negative axillary status in cT2\u20103 breast cancer patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This study was a prospective, single\u2010centre validation study conducted in the Breast and Endocrine Unit of the Department of Surgery and the Department of Pathology in a tertiary teaching hospital in central India from September 2022 to April 2024. Eligible participants included adult female patients (aged \u2265\u200918\u2009years) with core needle biopsy\u2010proven invasive breast cancer classified as cT2\u20103, cN0, and scheduled for primary surgical treatment. The primary outcomes were the Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) and accuracy of the AUS\u2009+\u2009TIC approach in predicting pathologically negative axillary status.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>AUS\u2009+\u2009TIC had a sensitivity of 100% (95% CI: 47.82%\u2013100%), a specificity of 100% (95% CI: 91.19%\u2013100%) and an overall accuracy of 100% (95% CI: 92.13%\u2013100%). There were no false negatives.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our findings suggest that the combination of AUS\u2009+\u2009TIC provides a reliable technique with high diagnostic accuracy, sensitivity, and specificity for assessing ALN in low resource settings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13484","type":"journal-article","created":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T06:59:34Z","timestamp":1743145174000},"page":"386-390","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Optimising Axillary Staging in Resource\u2010Constrained Settings: A Prospective Validation of Axillary Ultrasound and Touch Imprint Cytology in Predicting Pathologically Negative Axillae in <scp>cT2<\/scp>\u20103 Breast Cancer"],"prefix":"10.1111","volume":"36","author":[{"given":"Balmik","family":"Chaturvedi","sequence":"first","affiliation":[{"name":"Department of Pathology NSCB Medical College  Jabalpur Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muktesh","family":"Khandare","sequence":"additional","affiliation":[{"name":"Department of Pathology NSCB Medical College  Jabalpur Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Devashish","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis NSCB Medical College  Jabalpur Madhya Pradesh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0682-4970","authenticated-orcid":false,"given":"Sanjay Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Surgery NSCB Medical College  Jabalpur Madhya Pradesh 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