{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,7]],"date-time":"2025-10-07T09:10:04Z","timestamp":1759828204957,"version":"build-2065373602"},"reference-count":22,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T00:00:00Z","timestamp":1743984000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2025,11]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>The aim of this study was to evaluate the accuracy of detecting malignancies by directly sampled endometrial cytology using globally adopted ThinPrep with a novel preparation technique.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Medical records and reports of pathology and cytology from June 2019 to March 2022 were reviewed. We selected 112 endometrial cytology specimens using ThinPrep with the novel preparation technique, where the clinical course or pathological samples confirmed negative or positive results. Eight cytotechnologists or cytopathologists examined the cytology specimens and provided reports based on standardised criteria from the descriptive reporting system for endometrial cytology (the Yokohama System).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The 112 specimens were evenly smeared and well prepared, featuring high quality, with no issues hindering microscopic examination. Examiners unfamiliar with endometrial cytology using ThinPrep showed high diagnostic accuracy, demonstrating that this modality of preparation for endometrial cytology is feasible for clinical use.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The novel preparation method using ThinPrep successfully provided high\u2010quality, standardised specimens. Furthermore, employing the Yokohama System enabled high accuracy in detecting endometrial malignancies, even for examiners with minimal experience with this cytological technique. This suggests that ThinPrep\u2010based endometrial cytology can be globally adopted with ease, potentially contributing significantly to the early detection of endometrial cancer.<\/jats:p><\/jats:sec>","DOI":"10.1111\/cyt.13488","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T13:40:54Z","timestamp":1744033254000},"page":"572-577","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Diagnostic Accuracy of Directly Sampled Endometrial Cytology Using <scp>ThinPrep<\/scp> for Endometrial Malignancies: Comparison With Existing Endometrial Liquid\u2010Based Cytology"],"prefix":"10.1111","volume":"36","author":[{"given":"Rie","family":"Ikemoto","sequence":"first","affiliation":[{"name":"Department of Laboratory Medicine SRL Advanced Lab. FMA, SRL, Inc.  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Tanikawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Yame General Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Morio","family":"Ijichi","sequence":"additional","affiliation":[{"name":"Deputy Chief of Medical Clinic Ohbuchi Clinic  Miyazaki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miyoko","family":"Miyakawa","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Yame General Hospital  Fukuoka Japan"},{"name":"Department of Gynecology Yame Public Hospital  Fukuoka Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3842-6763","authenticated-orcid":false,"given":"Kenji","family":"Yanoh","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology JA Suzuka General Hospital  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Watanabe","sequence":"additional","affiliation":[{"name":"PCL Japan Pathology and Cytology Center PCL Inc.  Kawagoe Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yutaka","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Pathology JA Suzuka General Hospital  Mie Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken","family":"Maruyama","sequence":"additional","affiliation":[{"name":"PCL Japan Pathology and Cytology Center PCL Inc.  Kawagoe Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8557-9207","authenticated-orcid":false,"given":"Tadao K.","family":"Kobayashi","sequence":"additional","affiliation":[{"name":"Educational Institution Tenri University Member of the Board  Tenri Nara Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideaki","family":"Hirai","sequence":"additional","affiliation":[{"name":"Department of Diagnostic Pathology Tokyo Medical University Hospital  Tokyo Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Noriyuki","family":"Furuta","sequence":"additional","affiliation":[{"name":"PCL Japan Pathology and Cytology Center PCL Inc.  Kawagoe Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5788-3356","authenticated-orcid":false,"given":"Yasuo","family":"Hirai","sequence":"additional","affiliation":[{"name":"PCL Japan Pathology and Cytology Center PCL Inc.  Kawagoe Saitama Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,7]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm12062358"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000357769"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.12657"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1159\/000502108"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000455890"},{"volume-title":"ThinPrep Endometrial Cytology Atlas","year":"2023","author":"Ikemoto R.","key":"e_1_2_11_7_1"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23916"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-981-16-5011-6"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-7020-3154-0.00026-0"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/cyt.13087"},{"volume-title":"Atolante di Citologia Endometrialle: L'endometrio Normale, Iperplastico e Neoplastico Nella Citologia in Fase Liquida","year":"2005","author":"Taddei G. 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