{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T10:29:47Z","timestamp":1782988187103,"version":"3.54.5"},"reference-count":54,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T00:00:00Z","timestamp":1745452800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>Identifying aggressive variants of throid papillary carcinoma correctly is paramount, as their diagnosis requires more extensive surgical interventions. Numerous cytologic scoring systems have been proposed to distinguish non\u2010aggressive from aggressive variants. Oncocytic morphology is characterised by cells with abundant granular cytoplasm resulting from mitochondrial accumulation. This feature is particularly prominent in specific PTC variants. Tall cell and hobnail variants are aggressive variants with oncocytic morphology. The present study aims to evaluate the cytomorphological features of 51 histologically confirmed papillary thyroid carcinoma (PTC) cases with oncocytic morphology and to identify cytological features that could facilitate the distinction between aggressive (tall cell and hobnail) and non\u2010aggressive (oncocytic and Warthin\u2010like) variants during the FNA stage, thereby enabling early detection of aggressive variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively examined the cytological features of cases diagnosed with histologically confirmed aggressive variants with poor prognosis (tall cell and hobnail) and non\u2010aggressive variants with good prognosis (oncocytic and Warthin\u2010like), obtained from the pathology department of our hospital between 2014 and 2020.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      39 cases (76.5%) classified into the good prognosis group, which included oncocytic variant (O\u2010PTC) (33 cases) and Warthin\u2010like variant (WL\u2010PTC) (6 cases). The poor prognosis group included 12 cases (23.5%), comprising hobnail variant (HN\u2010PTC) (2 cases) and tall cell variant (TC\u2010PTC) (10 cases). The swirl pattern was significantly more frequent in the poor prognosis group (83.3% vs. 43.6%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.022), with a sensitivity of 83.3% and specificity of 56.4%. The presence of nuclear grooves was observed in all cases of the poor prognosis group (100%) while in 61.5% of the good prognosis group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.011). This feature exhibited 100% sensitivity and 38.4% specificity. Concerning cytoplasmic volume, scant\u2010medium amount cytoplasmic volume was significantly more common in the poor prognosis group (66.7% vs. 20.5%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.005), showing 66.7% sensitivity and 79.4% specificity, and yielding the highest accuracy rate (76.4%) among all characteristics.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Oncocytic morphology\u2010based approaches may help identify poor prognosis variants and guide clinical decisions. In our study, cellular swirls, grooves and scant\u2010medium cytoplasmic volume were the most significant cytological indicators for identifying poor prognosis variants. Despite previous emphasis on cell width\/height ratio and foamy INCIs for TC\u2010PTC diagnosis, no significant differences were found between the two groups in our study.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cyt.13502","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T23:58:19Z","timestamp":1745539099000},"page":"53-65","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Can Aggressive Papillary Thyroid Carcinoma Variants With Oncocyt\u0131c Morphology (Tall Cell and Hobnail Variants) be Detected Cytologically? Is the Differentiation as Straightforward as Reported?"],"prefix":"10.1111","volume":"37","author":[{"given":"Burcu","family":"\u00d6zcan","sequence":"first","affiliation":[{"name":"Department of Pathology University of Health Science, Istanbul Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merve","family":"Cin","sequence":"additional","affiliation":[{"name":"Department of Pathology University of Health Science, Istanbul Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2009-4505","authenticated-orcid":false,"given":"Zeynep Ece","family":"Demirba\u015f","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital  Istanbul Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,24]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"WHO Classification of Tumours Online \u201cEndocrine and Neuroendocrine Tumours (5th ed.) \u201daccessed February 13 2025 https:\/\/tumourclassifiction.iarc.who.int\/chaptercontent\/53\/44."},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.21417"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23703"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0020"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0274"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2017.0500"},{"issue":"9","key":"e_1_2_10_8_1","first-page":"1039","article-title":"The 2023 Bethesda System for Reporting Thyroid Cytopathology","volume":"33","author":"Ali S. 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