{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T01:12:52Z","timestamp":1775610772431,"version":"3.50.1"},"reference-count":47,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T00:00:00Z","timestamp":1745539200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Objective<\/jats:title>\n \n Micronucleus (\n MN<\/jats:styled-content>\n ) and Nuclear Budding (\n NB<\/jats:styled-content>\n ) Have Been Used as an Important Stimulus for Nuclear Atypia in Revealing Chromosomal Damage and Cancer Risk. This Study Aims to Assess\n MN<\/jats:styled-content>\n and\n NB<\/jats:styled-content>\n as Nuclear Parameters and Explore Their Role in Differential Diagnosis of Thyroid\n FNA<\/jats:styled-content>\n and \u201cBethesda System for Reporting Thyroid Cytology\u201d (\n BSRTC<\/jats:styled-content>\n ).\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n The Study Included 350 Thyroid\n FNA<\/jats:styled-content>\n Samples Categorised According to\n BSRTC<\/jats:styled-content>\n .\n NB<\/jats:styled-content>\n And\n MN<\/jats:styled-content>\n Were Evaluated in 1000 Thyrocytes on\n FNA<\/jats:styled-content>\n Slides. The Thyroidectomy Sections Were Divided Into Three Categories as \u2018Malignant\u2019, \u2018Low\u2010Risk\u2019 and \u2018Benign\u2019.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n A Total of 350 Cases Were Classified as follows: 55 (15.71%) Benign, 159 (45.43%) Atypia of Undetermined Significance (\n AUS<\/jats:styled-content>\n ), 20 (5.71%) Follicular Neoplasm (\n FN<\/jats:styled-content>\n ), 48 (13.71%) Suspicious for Malignancy (\n SFM<\/jats:styled-content>\n ) and 68 (19.43%) Malignant. In comparison to all other cytopathologic diagnostic groups, the benign group had significantly lower levels of MN and NB (\n p<\/jats:italic>\n \u2009<\u20090.001). The AUS group's MN and NB counts were significantly lower than those of the FN, SFM and malignant groups (MN for AUS\u2010FN\/SFM\/M\n p<\/jats:italic>\n \u2009<\u20090.001, NB for AUS\u2010FN\n p<\/jats:italic>\n \u2009=\u20090.01, NB for AUS\u2010SFM\/M\n p<\/jats:italic>\n \u2009<\u20090.001, respectively). MN and NB counts were greater in the AUS group for cases with a malignant histopathologic diagnosis than for those with a benign histopathologic diagnosis (\n p<\/jats:italic>\n \u2009<\u20090.001). MN and NB cut\u2010off values >\u20095.50 and\u2009>\u200914.50, respectively, suggest high sensitivity and specificity of malignancy.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n \n Increased Frequency of\n MN<\/jats:styled-content>\n and\n NB<\/jats:styled-content>\n closely associated with an increased risk of malignancy in thyroid\n FNA<\/jats:styled-content>\n . Assessing\n MN<\/jats:styled-content>\n and\n NB<\/jats:styled-content>\n in thyroid\n FNA<\/jats:styled-content>\n may help better stratify the risk in the\n AUS<\/jats:styled-content>\n category.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cyt.13505","type":"journal-article","created":{"date-parts":[[2025,4,26]],"date-time":"2025-04-26T00:28:53Z","timestamp":1745627333000},"page":"76-85","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Micronucleus and Nuclear Budding Help to Identify Malignancy in Thyroid Fine Needle Aspiration Cytology"],"prefix":"10.1111","volume":"37","author":[{"given":"Nur Gizem Kocao\u011flu","family":"\u00c7elik","sequence":"first","affiliation":[{"name":"Department of Pathology Ankara Bilkent City Hospital Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1484-7619","authenticated-orcid":false,"given":"Ay\u015feg\u00fcl Aksoy","family":"Alt\u0131nbo\u011fa","sequence":"additional","affiliation":[{"name":"Department of Pathology Ankara Bilkent City Hospital Ankara Turkey"},{"name":"Department of Pathology, Medical Faculty Ankara Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tuba Dilay K\u00f6kenek","family":"\u00dcnal","sequence":"additional","affiliation":[{"name":"Department of Pathology Ankara Bilkent City Hospital Ankara Turkey"},{"name":"Department of Pathology, Medical Faculty Ankara Yildirim Beyazit University Ankara Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,25]]},"reference":[{"issue":"3","key":"e_1_2_10_2_1","first-page":"559","article-title":"Thyroid Nodules","volume":"67","author":"Welker M. 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