{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T01:26:59Z","timestamp":1775179619880,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T00:00:00Z","timestamp":1755820800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n \n Thyroid tumours occur in patients with Birt\u2010Hogg\u2010Dub\u00e9 syndrome (BHD), a condition caused by germline alterations in the\n FLCN<\/jats:italic>\n gene that confers an increased cancer risk. Somatic\n FLCN<\/jats:italic>\n mutations may also contribute to tumorigenesis. In this study, we present the first description of the cytopathology of two thyroid tumours evaluated by fine\u2010needle aspiration (FNA) and harbouring pathogenic\n FLCN<\/jats:italic>\n mutations.\n <\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n We encountered two patients with oncocytic thyroid tumours in which comprehensive next\u2010generation sequencing (NGS) identified pathogenic\n FLCN<\/jats:italic>\n mutations. We present the FNA cytologic findings and corresponding histopathology, and discuss the diagnostic challenges posed by the FNAs, one of which was initially confounded by negative preoperative molecular testing.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Both patients were middle\u2010aged females. Patient 1 had an incidental thyroid nodule and a history of BHD. FNA of a TI\u2010RADS 5 mass was diagnosed as suspicious for papillary thyroid carcinoma (PTC), Bethesda V, leading to total thyroidectomy. Patient 2 presented with a palpable nodule. Compressive symptoms prompted lobectomy, revealing an angioinvasive oncocytic carcinoma. Subsequent FNA findings of a metastasis cytologically resembled oncocytic PTC; however, it was correctly diagnosed as oncocytic carcinoma after correlation with prior histologic findings. Expanded NGS testing facilitated the final diagnosis of\n FLCN<\/jats:italic>\n \u2010mutated oncocytic adenoma in Patient 1 and high\u2010grade differentiated oncocytic carcinoma in Patient 2.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion<\/jats:title>\n \n Thyroid tumours harbouring\n FLCN<\/jats:italic>\n mutations with oncocytic features may mimic PTC cytologically. Although rare, correct diagnosis of these tumours is essential to ensure appropriate treatment. For early detection, patients with BHD may benefit from thyroid ultrasound surveillance.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cyt.70019","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T12:40:33Z","timestamp":1755866433000},"page":"108-115","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Oncocytic Thyroid Tumours With Pathogenic\n \n FLCN<\/i>\n <\/scp>\n Mutations Mimic Oncocytic Papillary Thyroid Carcinoma on Fine\u2010Needle Aspiration"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-5200-4484","authenticated-orcid":false,"given":"Adeel M.","family":"Ashraf","sequence":"first","affiliation":[{"name":"Department of Pathology & Laboratory Medicine University of Kentucky College of Medicine Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Faisal","family":"Hassan","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine University of Kentucky College of Medicine Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adrian A.","family":"Dawkins","sequence":"additional","affiliation":[{"name":"Department of Radiology University of Kentucky College of Medicine Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie C.","family":"Dueber","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine University of Kentucky College of Medicine Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5119-2474","authenticated-orcid":false,"given":"Derek B.","family":"Allison","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine University of Kentucky College of Medicine Lexington Kentucky USA"},{"name":"Markey Cancer Center Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0899-9405","authenticated-orcid":false,"given":"Th\u00e8r\u00e9se J.","family":"Bocklage","sequence":"additional","affiliation":[{"name":"Department of Pathology & Laboratory Medicine University of Kentucky College of Medicine Lexington Kentucky USA"},{"name":"Markey Cancer Center Lexington Kentucky USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1977.01640120042005"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg.2007.054304"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrurol.2015.206"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000003695"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365\u20102133.2009.09517.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1210\/clinem\/dgad136"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1159\/000510241"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/cup.14799"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/curroncol32040224"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1136\/jmg\u20102022\u2010109104"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvab048.1803"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.12688\/f1000research.4205.1"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.3454"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2021.01.005"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1210\/jendso\/bvad114.2033"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2024.10.11"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2021.701877"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22374"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.22375"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncy.70016"},{"issue":"7","key":"e_1_2_8_22_1","first-page":"7988","article-title":"Cytologic, Clinicopathologic, and Molecular Features of Papillary Thyroid Carcinoma With Prominent Hobnail Features: 10 Case Reports and Systematic Literature Review","volume":"8","author":"Lee Y. 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