{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:19:11Z","timestamp":1770819551369,"version":"3.50.1"},"reference-count":12,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T00:00:00Z","timestamp":1757462400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:p>Mediastinal masses often present acutely as medical emergencies, necessitating prompt and accurate diagnosis. Imaging\u2010guided fine needle aspiration cytology (FNAC) plays a pivotal role in rapidly identifying rare mediastinal tumours and differentiating them from other potential aetiologies, enabling timely intervention. Primary mediastinal germ cell tumours (PMGCTs) constitute approximately 15% of adult mediastinal neoplasms. The development of somatic\u2010type malignancies, particularly colonic\u2010type adenocarcinoma, in PMGCTs is rare and typically associated with a poor prognosis. Combining cytological findings with imaging, serum tumour marker analysis and immunohistochemistry can facilitate the detection of various germ cell components and aid in diagnosing GCTs. We report the case of a 35\u2010year\u2010old male presenting with symptoms of mediastinal compression. Contrast\u2010enhanced computed tomography (CECT) revealed an ill\u2010defined anterior mediastinal lesion measuring 9.2\u2009cm in maximum dimension with a heterogeneous appearance. Emergency ultrasound\u2010guided FNAC was performed, yielding highly cellular smears that showed malignant epithelial cell clusters with intracytoplasmic and extracellular mucin, as well as strips and clusters of benign intestinal epithelial cells. Based on the cytomorphological features, the patient's age and imaging findings, a diagnosis of somatic\u2010type adenocarcinoma arising in a background of teratoma was suggested. Histopathological examination of the excised mass confirmed the cytological diagnosis. Adenocarcinoma in the mediastinum may arise from primary sites such as the aerodigestive tract or represent metastatic disease. However, in this case, the presence of a benign intestinal epithelial component strongly indicated a teratomatous origin. This report underscores the utility of imaging\u2010guided FNAC as a minimally invasive and effective diagnostic tool, enabling early diagnosis and timely treatment initiation in patients presenting with acute mediastinal obstruction.<\/jats:p>","DOI":"10.1111\/cyt.70021","type":"journal-article","created":{"date-parts":[[2025,9,10]],"date-time":"2025-09-10T09:38:33Z","timestamp":1757497113000},"page":"195-200","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Mediastinal Teratoma With Somatic\u2010Type Adenocarcinoma: An Enigmatic Discovery by Fine Needle Aspiration Cytology"],"prefix":"10.1111","volume":"37","author":[{"given":"Swetha","family":"Venkatakrishnan","sequence":"first","affiliation":[{"name":"Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9370-5063","authenticated-orcid":false,"given":"Soundarya","family":"Ravi","sequence":"additional","affiliation":[{"name":"Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3880-9150","authenticated-orcid":false,"given":"Debasis","family":"Gochhait","sequence":"additional","affiliation":[{"name":"Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bhawana A.","family":"Badhe","sequence":"additional","affiliation":[{"name":"Department of Pathology Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ramsankar","family":"Padmanabhan","sequence":"additional","affiliation":[{"name":"Department of Cardiothoracic and Vascular Surgery Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER)  Puducherry India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,10]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.seminoncol.2019.04.001"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CCO.0b013e32835f085d"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.athoracsur.2009.12.081"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/101.4.531"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0b013e318033c7c4"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2021-0108-RA"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.23975"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.23983"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1066896910390680"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2020.04.008"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2303.1998.00088.x"},{"key":"e_1_2_8_13_1","article-title":"Mediastinal Germ Cell Tumours: Where We Are and Where We Are Going\u2014A Narrative Review","volume":"6","author":"Marandino 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