{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T13:55:51Z","timestamp":1765288551628,"version":"3.46.0"},"reference-count":28,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2025,9,19]],"date-time":"2025-09-19T00:00:00Z","timestamp":1758240000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Participation in diagnostic intercomparison programs is a mandatory requirement for accreditation of cytology laboratories. Results described by these programs in cervico vaginal cytology (CVC) show a significant number of discrepancies. We hypothesised whether the use of IA systems, such as the ThinPrep Genius system, would improve diagnostic concordance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We simulated an intercomparison program between two centres in which four observers used the same 30 cases of CVC with negative diagnoses, ASCUS, LSIL and HSIL and observed them with light optic microscopy (OM) and two Genius (G1 and G2) systems, one from each centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The diagnostic agreement between OM and the two Genius was similar, with overall agreement values of 82% for G1 and 78% for G2 and OM, and similar kappa values for the three techniques. However, both Genius diagnosed glandular lesions that were not included in the selected cases and were not diagnosed with OM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The concordance obtained in both OM and Genius is acceptable and falls within the range of that obtained in what is described in intercomparison programs. We must consider the greater affinity for diagnosing glandular lesions with Genius and the fact that there may be discrete differences between two different devices, probably due to calibration.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cyt.70025","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T04:35:47Z","timestamp":1758342947000},"page":"45-52","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Intercenter Study of Interobserver Variability With Optical and Digital Imaging in Cervicovaginal Cytology. Simulation of a Quality Control Program"],"prefix":"10.1111","volume":"37","author":[{"given":"Francesc","family":"Tresserra","sequence":"first","affiliation":[{"name":"Cytology Laboratory, Department of Obstetrics, Gynecology and Reproduction Hospital Universitari Dexeus  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carme","family":"Dinar\u00e8s","sequence":"additional","affiliation":[{"name":"Cytology Laboratory, Department of Pathology Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga","family":"Luque","sequence":"additional","affiliation":[{"name":"Cytology Laboratory, Department of Obstetrics, Gynecology and Reproduction Hospital Universitari Dexeus  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marta","family":"Serra","sequence":"additional","affiliation":[{"name":"Cytology Laboratory, Department of Pathology Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miriam","family":"Castella","sequence":"additional","affiliation":[{"name":"Cytology Laboratory, Department of Obstetrics, Gynecology and Reproduction Hospital Universitari Dexeus  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lucia","family":"Retamales","sequence":"additional","affiliation":[{"name":"Cytology Laboratory, Department of Pathology Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gemma","family":"Fabra","sequence":"additional","affiliation":[{"name":"Cytology Laboratory, Department of Obstetrics, Gynecology and Reproduction Hospital Universitari Dexeus  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Santiago","family":"Valera","sequence":"additional","affiliation":[{"name":"Cytology Laboratory, Department of Pathology Vall d'Hebron University Hospital  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ignacio","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Epidemiology Unit, Department of Obstetrics, Gynecology and Reproduction Hospital Universitari Dexeus  Barcelona Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,19]]},"reference":[{"volume-title":"Laboratorios Cl\u00ednicos Requisitos para la Calidad y la Competencia","year":"2023","author":"ISO 15189:2022","key":"e_1_2_10_2_1"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.patol.2017.11.003"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.5858\/arpa.2015-0446-CP"},{"key":"e_1_2_10_5_1","unstructured":"\u201cInterpretive Digital Diagnostic Cytopathology [Internet] \u201d accessed May 30 2025 https:\/\/www.ukneqascpt.org\/ieqa."},{"key":"e_1_2_10_6_1","unstructured":"\u201cPAP\u2010A 2023: Gynecologic Cytology Program | College of American Pathologists [Internet] \u201d accessed May 30 2025 https:\/\/education.cap.org\/content\/pap\u20102023\u2010gynecologic\u2010cytology\u2010program."},{"key":"e_1_2_10_7_1","unstructured":"\u201cDiagnostic Cytopathology Scheme [Internet] \u201d accessed May 30 2025 https:\/\/www.ukneqascpt.org\/non\u2010gynae."},{"key":"e_1_2_10_8_1","unstructured":"\u201cControl de Calidad\u2014secitologia.org [Internet] \u201d accessed May 31 2025 https:\/\/secitologia.org\/control\u2010de\u2010calidad\/."},{"key":"e_1_2_10_9_1","unstructured":"\u201cMemoria de Actividad del Programa de Control de Calidad de la Sociedad Espa\u00f1ola de Citolog\u00eda (SEC). 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