{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:19:08Z","timestamp":1770819548042,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T00:00:00Z","timestamp":1761004800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2026,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Anaplastic large cell lymphoma (ALCL) is a rare and aggressive subtype of non\u2010Hodgkin lymphoma characterised by large, anaplastic lymphoid cells with strong CD30 expression. Although ALCL commonly presents with nodal and extranodal involvement, pleural effusion as an initial manifestation is exceedingly uncommon. Pleural fluid involvement generally indicates advanced disease, often resulting from direct pleural infiltration or systemic dissemination, and is associated with a poor prognosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>We report the case of a 21\u2010year\u2010old female who presented with fever, abdominal pain, breathlessness, and significant weight loss. Clinical evaluation revealed generalized lymphadenopathy and a left\u2010sided pleural effusion. Cytologic examination of the pleural fluid showed dispersed large atypical lymphoid cells with irregular nuclear contours, prominent nucleoli, and abundant vacuolated cytoplasm. Immunocytochemistry on the cell block demonstrated strong CD30 and ALK positivity, confirming the diagnosis of ALK\u2010positive ALCL, which was subsequently corroborated by inguinal lymph node biopsy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Outcome<\/jats:title>\n                    <jats:p>The patient was promptly started on CHOP chemotherapy. Despite early initiation of treatment, her condition rapidly deteriorated, and she succumbed to the disease within 2\u2009weeks of diagnosis, reflecting the fulminant nature of effusion\u2010positive ALCL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Message<\/jats:title>\n                    <jats:p>This case highlights the diagnostic value of effusion cytology combined with cell block immunocytochemistry in establishing a definitive diagnosis of ALCL from pleural fluid, even in the absence of an overt mass lesion. Early recognition of this rare presentation is critical for timely management, as effusion\u2010dominant ALCL may portend an aggressive clinical course.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cyt.70029","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T04:35:57Z","timestamp":1761107757000},"page":"175-183","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Pleural Fluid Homing by Anaplastic Large Cell Lymphoma\u2013Cytopathologic Diagnosis of a Rare Presentation"],"prefix":"10.1111","volume":"37","author":[{"given":"Nithye","family":"Parvathy","sequence":"first","affiliation":[{"name":"Department of Cytology and Gynecologic Pathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amanjit","family":"Bal","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pankaj","family":"Malhotra","sequence":"additional","affiliation":[{"name":"Department of Clinical Hematology and Medical Oncology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2159-4325","authenticated-orcid":false,"given":"Parikshaa","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynecologic Pathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,10,21]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V91.6.2076"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2014-10-567461"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-01-134270"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2012.42.2345"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/dc.20432"},{"key":"e_1_2_9_7_1","first-page":"87","article-title":"Anaplastic Large Cell Lymphoma Manifesting as Pleural Effusion in a Patient With Long\u2010Standing Eosinophilia","volume":"50","author":"Belludi C. 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