{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T13:08:53Z","timestamp":1775653733692,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,3]],"date-time":"2026-01-03T00:00:00Z","timestamp":1767398400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Medullary thyroid carcinoma (MTC) is a rare malignant tumour of the thyroid gland that originates from parafollicular cells. Although rare, MTC is aggressive, so early detection is important for improving prognosis. The accuracy of fine\u2010needle aspiration cytology (FNAC) for diagnosing MTC is still controversial.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The data of 20 patients who underwent thyroid FNAC with histological follow\u2010up to diagnose MTC between 2016 and 2024 were retrospectively collected from The First Affiliated Hospital of Soochow University. Cytological findings, histological features, and serological testing were reviewed, and causes of misdiagnosis were evaluated.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The diagnostic accuracy of FNAC was 90% (18\/20). Two patients were initially misdiagnosed with suspected papillary thyroid carcinoma, while eighteen patients were accurately diagnosed in the first instance with suspected MTC. Cytopathological analysis revealed plasmacytoid and spindle\u2010like characteristics with \u2018salt and pepper\u2019 chromatin distributed in the nuclei, with occasional giant tumour cells and frequent deposition of pink\u2010stained amyloid in the background. In addition, serum calcitonin and carcinoembryonic antigen were elevated to varying degrees.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Fine\u2010needle aspiration is a highly valuable method for the preoperative diagnosis of MTC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cyt.70048","type":"journal-article","created":{"date-parts":[[2026,1,4]],"date-time":"2026-01-04T04:15:44Z","timestamp":1767500144000},"page":"255-262","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of Diagnostic Accuracy of Medullary Thyroid Carcinoma Using Fine\u2010Needle Aspiration Cytology\u2014Based on a Single Tertiary Centre Experience"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-0155-9379","authenticated-orcid":false,"given":"Si\u2010Yi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong\u2010Mei","family":"Gu","sequence":"additional","affiliation":[{"name":"Department of Pathology The First Affiliated Hospital of Soochow University  Suzhou Jiangsu China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,3]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0110"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/cen.12563"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ecl.2008.03.001"},{"issue":"18","key":"e_1_2_11_6_1","first-page":"191","article-title":"Diagnosis of Medullary Thyroid Carcinoma by Fine\u2010Needle Aspiration Cytology: A Report of 4 Cases","volume":"13","author":"Xuejun Z.","year":"2023","journal-title":"China Medicine and 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