{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:24:50Z","timestamp":1787142290489,"version":"build-2736575974"},"reference-count":40,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["ROR identifier: 00x0ma614"],"award-info":[{"award-number":["ROR identifier: 00x0ma614"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002322","name":"Coordena\u00e7\u00e3o de Aperfei\u00e7oamento de Pessoal de N\u00edvel Superior","doi-asserted-by":"publisher","award":["CAPES\u2014Finance Code 001"],"award-info":[{"award-number":["CAPES\u2014Finance Code 001"]}],"id":[{"id":"10.13039\/501100002322","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>This study aimed to characterise the local cytokine milieu in the cervicovaginal environment of women with HSIL compared with healthy controls.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this case\u2013control study, cervical samples were collected from 84 women aged 20\u201349\u2009years, including 57 patients with histologically confirmed HSIL and 27 healthy controls. Levels of IL\u20102, IL\u20104, IL\u20106, IL\u201010, TNF, IFN\u2010\u03b3 and IL\u201017A were quantified in cervicovaginal lavage fluid using a Cytometric Bead Array. Cytokine ratios were calculated to assess the balance between pro\u2010inflammatory and regulatory immune responses. Statistical comparisons between groups were performed using the Mann\u2013Whitney test.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Women with HSIL exhibited significantly lower concentrations of TNF (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.030) and IL\u20102 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.010) compared with controls. Correspondingly, the TNF\/IL\u201010 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018) and TNF\/IL\u20104 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032) ratios were markedly decreased, suggesting impaired Th1\u2010mediated immune activation. No significant differences were observed for IL\u201017A levels or IL\u201017A\/IL\u20106 ratios, suggesting that Th17\u2010associated soluble mediators may not be the predominant drivers of the observed immunomodulation in this context, although broader Th17 involvement cannot be excluded.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>HSIL is characterised by reduced TNF and IL\u20102 expression and a suppressed TNF\/IL\u201010 and TNF\/IL\u20104 balance, revealing a shift towards an immunoregulatory profile independent of Th17 activity. This cytokine signature suggests an immune milieu favouring lesion persistence and provides a potential framework for developing cytokine\u2010based biomarkers and immunotherapeutic strategies in HPV\u2010associated cervical disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cyt.70105","type":"journal-article","created":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T04:41:38Z","timestamp":1782967298000},"page":"523-530","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cervical Cytokine Profile in High\u2010Grade Squamous Intraepithelial Lesions"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0009-0008-4198-2887","authenticated-orcid":false,"given":"Talles Henrique","family":"de Ara\u00fajo Pontes","sequence":"first","affiliation":[{"name":"Postgraduate Program in Science Applied to Women's Health Federal University of Rio Grande Do Norte  Natal 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