{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T12:24:52Z","timestamp":1787142292259,"version":"build-2736575974"},"reference-count":32,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"published-print":{"date-parts":[[2026,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Human papillomavirus (HPV) infection is a major risk factor for cervical, anal, and oropharyngeal cancers, particularly in people living with HIV (PWH), who face higher HPV prevalence, especially in men who have sex with men (MSM). Limited data on HPV in Mexican PWH highlight the need for targeted screening.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>To assess the prevalence of anal cytological abnormalities in PWH and their association with high\u2010risk HPV genotypes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A cross\u2010sectional study (2023\u20132025) at Hospital de Infectolog\u00eda \u2018La Raza\u2019, Mexico City, included 137 PWH with confirmed high\u2010risk HPV. Anal cytology and PCR based HPV genotyping for 28 genotypes were conducted. Multivariate logistic regression adjusted for confounders, including vaccination status.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Multiple high\u2010risk HPV genotypes (&gt;\u20093) were linked to abnormal cytology (OR 3.094, 95% CI 1.297\u20137.383,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.009) and ASC\u2010US (OR 3.060, 95% CI 1.177\u20137.954,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.018). HPV 16+59 increased ASC\u2010US risk (OR 5.450, 95% CI 1.259\u201323.600,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.032). Vaccination reduced risks for abnormal cytology (OR 0.331, 95% CI 0.116\u20130.948,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.039) and ASC\u2010US (OR 0.209, 95% CI 0.053\u20130.823,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.025).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>High\u2010risk HPV genotypes 16 and 59 and multiple HPV infections are risk factors for anal cytological abnormalities in PWH. Vaccination is protective, supporting enhanced screening and vaccination strategies to reduce HPV\u2010related cancer risks.<\/jats:p>\n                    <jats:p>\n                      <jats:bold>Trial Registration:<\/jats:bold>\n                      ClinicalTrials.gov identifier: R\u20102025\u20103502\u2010052\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cyt.70106","type":"journal-article","created":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:09:28Z","timestamp":1783483768000},"page":"544-554","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genotypes and Risk Factors for Anal Cytological Abnormalities in People Living With\n                    <scp>HIV<\/scp>\n                    and High\u2010Risk Human Papillomavirus: The\n                    <scp>GAIA<\/scp>\n                    2 Study Cytological Abnormalities in People Living With\n                    <scp>HIV<\/scp>\n                    and High\u2010Risk Human Papillomavirus"],"prefix":"10.1111","volume":"37","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9659-746X","authenticated-orcid":false,"given":"Ana Luz","family":"Cano\u2010D\u00edaz","sequence":"first","affiliation":[{"name":"Infectious Diseases Department Hospital de Infectolog\u00eda \u201cLa Raza\u201d, National Medical Center, Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omar","family":"Hern\u00e1ndez\u2010L\u00f3pez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital de Infectolog\u00eda \u201cLa Raza\u201d, National Medical Center, Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 Antonio","family":"Mata\u2010Mar\u00edn","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital de Infectolog\u00eda \u201cLa Raza\u201d, National Medical Center, Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Javier Vicente","family":"Noyola\u2010G\u00f3mez","sequence":"additional","affiliation":[{"name":"Gynecology Department, Hospital de Infectolog\u00eda \u201cLa Raza\u201d, National Medical Center Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S\u00f3crates Alberto","family":"Garc\u00eda\u2010Guti\u00e9rrez","sequence":"additional","affiliation":[{"name":"Pathology Department, Hospital de Especialidades \u201cDr. Antonio Fraga Mouret\u201d, \u201cLa Raza\u201d National Medical Center Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ericka Nelly","family":"Pompa\u2010Mera","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital de Infectolog\u00eda \u201cLa Raza\u201d, National Medical Center, Instituto Mexicano del Seguro Social  Mexico City Mexico"},{"name":"Research Unit, Hospital de Infectolog\u00eda \u201cLa Raza\u201d, National Medical Center Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brenda Clara","family":"Gonz\u00e1lez\u2010Contreras","sequence":"additional","affiliation":[{"name":"Medicine School Universidad Aut\u00f3noma Metropolitana  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-0700-2081","authenticated-orcid":false,"given":"Paola Edith","family":"Padilla\u2010Noguera","sequence":"additional","affiliation":[{"name":"Medicine School, Facultad de Estudios Superiores Iztacala Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Chaparro\u2010S\u00e1nchez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital de Infectolog\u00eda \u201cLa Raza\u201d, National Medical Center, Instituto Mexicano del Seguro Social  Mexico City Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jes\u00fas Enrique","family":"Gaytan\u2010Mart\u00ednez","sequence":"additional","affiliation":[{"name":"Infectious Diseases Department Hospital de Infectolog\u00eda \u201cLa Raza\u201d, National Medical Center, Instituto Mexicano del Seguro Social  Mexico City 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