{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T08:07:04Z","timestamp":1788941224928,"version":"build-2803163510"},"reference-count":17,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T00:00:00Z","timestamp":1788912000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Ovarian neoplasms are a significant cause of morbidity among women, particularly in resource\u2010limited rural settings where access to advanced diagnostic facilities is often restricted. Intraoperative cytology provides a rapid and cost\u2010effective diagnostic adjunct that may facilitate timely surgical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aim<\/jats:title>\n                    <jats:p>To evaluate the diagnostic utility of minimally invasive techniques of cytology in ovarian tumours in a rural tertiary care centre.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>This study has been conducted by the Departments of Pathology, Obstetrics and Gynecology, by analysing cytological samples obtained from ovarian cysts\/tumours retrospectively between June 2023 and December 2025. This includes specimen of ovarian mass\/cysts submitted for touch\/imprint, scrape and crush smears, along with fine\u2010needle aspiration cytology (FNAC) for intra\u2010operative cytological (IOC) assessment. FNA aspirates from ovarian masses obtained intra\u2010operatively were centrifuged at 3500\u2009rpm for 2\u20133\u2009min and sediment smears were examined. Cytological diagnoses obtained intra\u2010operatively were compared with histopathological findings, which served as the gold standard. Data were analysed for age distribution, concordance between cytology and histology, and diagnostic performance parameters including sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of 79 cases have been included in the study, and nine cases were excluded due to lack of relevant data for histopathological correlation. The age of patients ranged between 14 and 77\u2009years, with a peak incidence in the 41\u201350\u2010year age group (31.4%). Cytology showed concordance with histopathology in 61 out of 70 cases (87.1%), while 9 cases (12.9%) were discordant. For detection of malignancy, cytology demonstrated a sensitivity of 80%, specificity of 100%, PPV of 100% and NPV of 98.1%, with an overall diagnostic accuracy of 98.3%. No false\u2010positive cases were identified, while one false\u2010negative case was noted. The kappa coefficient was 0.88 with diagnostic accuracy being 98.3%.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cytology is a rapid, reliable and highly specific diagnostic tool for ovarian tumours, particularly valuable in rural tertiary care settings where access to advanced diagnostics may be limited. Its high specificity and PPV make it especially useful for differentiating between benign and malignant complex ovarian cysts and aiding early clinical decision\u2010making.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cyt.70115","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:35:34Z","timestamp":1788939334000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Bridging the Frozen Section Gap: Diagnostic Utility of Intraoperative Cytology in Ovarian Tumours From a Rural Tertiary Care Centre in South India"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2878-7752","authenticated-orcid":false,"given":"Y. C.","family":"Spoorthy Rekha","sequence":"first","affiliation":[{"name":"Department of Pathology Sri Madhusudan Sai Institute of Medical Sciences and Research  Chikkaballapur Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K. R.","family":"Ram Kumar","sequence":"additional","affiliation":[{"name":"Department of Pathology Sri Madhusudan Sai Institute of Medical Sciences and Research  Chikkaballapur Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Padmasri","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sri Madhusudan Sai Institute of Medical Sciences and Research  Chikkaballapur Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-3710-2016","authenticated-orcid":false,"given":"T. D.","family":"Nandeesha","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sri Madhusudan Sai Institute of Medical Sciences and Research  Chikkaballapur Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T. G.","family":"Vivek","sequence":"additional","affiliation":[{"name":"Department of Pathology Sri Madhusudan Sai Institute of Medical Sciences and Research  Chikkaballapur Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Archana","sequence":"additional","affiliation":[{"name":"Department of Pathology Sri Madhusudan Sai Institute of Medical Sciences and Research  Chikkaballapur Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akkamahadevi C.","family":"Hiremath","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sri Madhusudan Sai Institute of Medical Sciences and Research  Chikkaballapur Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brunda","family":"Muniswamy","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology Sri Madhusudan Sai Institute of Medical Sciences and Research  Chikkaballapur Karnataka India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,9]]},"reference":[{"issue":"3","key":"e_1_2_12_2_1","first-page":"209","article-title":"Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide","volume":"71","author":"Sung H.","year":"2021","journal-title":"CA: A Cancer Journal for Clinicians"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1002\/bjs.1800155810","article-title":"A New Method for the Rapid Microscopical Diagnosis of Tumors","volume":"15","author":"Dudgeon L. 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D.","year":"2004","journal-title":"International Journal of Gynecological Pathology"},{"issue":"3","key":"e_1_2_12_9_1","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1007\/s00428-012-1203-5","article-title":"Ovarian Carcinomas: Five Distinct Diseases With Different Origins, Genetic Alterations, and Clinicopathological Features","volume":"460","author":"Prat J.","year":"2012","journal-title":"Virchows Archiv"},{"issue":"3","key":"e_1_2_12_10_1","first-page":"131","article-title":"Scrape Cytology of Ovarian Neoplasms: Diagnostic Accuracy and Limitations","volume":"28","author":"Khunamornpong S.","year":"2003","journal-title":"Diagnostic Cytopathology"},{"issue":"4","key":"e_1_2_12_11_1","first-page":"550","article-title":"Scope of Intraoperative Cytology in Ovarian Neoplasms","volume":"48","author":"Rekhi B.","year":"2004","journal-title":"Acta Cytologica"},{"issue":"3","key":"e_1_2_12_12_1","first-page":"83","article-title":"Role of Scrape Cytology in Ovarian Neoplasms","volume":"27","author":"Bandyopadhyay A.","year":"2010","journal-title":"Journal of Cytology"},{"issue":"8","key":"e_1_2_12_13_1","first-page":"e345","article-title":"Intraoperative Cytology in Ovarian Tumors: Diagnostic Accuracy and Clinicopathological Correlation","volume":"52","author":"Mangla M.","year":"2024","journal-title":"Diagnostic Cytopathology"},{"issue":"6","key":"e_1_2_12_14_1","doi-asserted-by":"crossref","first-page":"682","DOI":"10.1002\/dc.24722","article-title":"Accuracy of Imprint Cytology and Frozen Section Histology for Intraoperative Diagnosis of Ovarian Epithelial Tumors: A Comparative Study and Proposed Algorithm","volume":"49","author":"Nomura N.","year":"2021","journal-title":"Diagnostic Cytopathology"},{"issue":"4","key":"e_1_2_12_15_1","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1007\/s13193-022-01597-5","article-title":"Utility of Scrape Cytology in Management of Ovarian Neoplasms: A Cross\u2010Sectional Study in a Tertiary Care Hospital of Eastern India","volume":"13","author":"Samaddar A.","year":"2022","journal-title":"Indian Journal of Surgical Oncology"},{"issue":"10","key":"e_1_2_12_16_1","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1002\/dc.25193","article-title":"Role of Scrape Cytology Smear Preparation in the Diagnosis of Ovarian Masses: Utility and Pitfalls","volume":"51","author":"Agarwal S.","year":"2023","journal-title":"Diagnostic Cytopathology"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1159\/000545110"},{"key":"e_1_2_12_18_1","doi-asserted-by":"crossref","DOI":"10.1016\/j.gore.2025.101757","article-title":"Concordance of Intraoperative Cytology With Frozen Section and Final Pathology for Ovarian Neoplasms","volume":"59","author":"Early J.","year":"2025","journal-title":"Gynecologic Oncology Reports"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.70115","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.70115","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.70115","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T07:35:37Z","timestamp":1788939337000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.70115"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,9]]},"references-count":17,"alternative-id":["10.1111\/cyt.70115"],"URL":"https:\/\/doi.org\/10.1111\/cyt.70115","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,9]]},"assertion":[{"value":"2026-06-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-09","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cyt.70115"}}