{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:05:24Z","timestamp":1790348724237,"version":"4.1.0"},"reference-count":13,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T00:00:00Z","timestamp":1790294400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"abstract":"ABSTRACT<\/jats:title>\n \n Background<\/jats:title>\n Cutaneous adnexal tumours are uncommon and are rarely diagnosed clinically. Occasionally, these cases are encountered during fine\u2010needle aspiration cytology (FNAC) performed as part of the routine evaluation of skin or subcutaneous tissue lesions.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n This retrospective study evaluated FNAC of skin adnexal tumours over a period of 10\u2009years. Smears stained with Papanicolaou and Giemsa stains were reviewed. Cytology diagnosis was correlated with histopathological diagnosis, wherever possible.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n A total of 34 cases of skin adnexal tumours were evaluated in the study. None of the cases had been diagnosed clinically. Most patients were in the 2nd\u20134th decades of life, with a male predominance. The head and neck region was the commonest site of involvement. Of the 34 cases, 32 (94.1%) were diagnosed as benign and 2 (5.9%) as malignant. Tumour subtyping on FNAC was possible in only 11 cases, comprising seven cases of pilomatrixoma and four cases of eccrine spiradenoma. Histopathological correlation was available in 13 cases, of which 10 showed concordance with the cytological diagnosis. The three discordant cases were pilomatrixoma and trichoblastoma, which had been misdiagnosed as malignant adnexal tumour on FNAC and a squamous carcinoma that was mistaken for a pilomatrixoma on FNAC.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n FNAC can play a valuable role in the preoperative diagnosis of cutaneous adnexal tumours. However, the cytological diagnosis of these tumours remains challenging. Correlation with clinical features, familiarity with the varied cytomorphological features and awareness of potential diagnostic pitfalls can minimise diagnostic errors.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/cyt.70131","type":"journal-article","created":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:56:20Z","timestamp":1790348180000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fine Needle Aspiration Cytology of Cutaneous Adnexal Tumours\u2014Navigating a Field Full of Landmines!"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2400-6151","authenticated-orcid":false,"given":"Abhishek","family":"Gawande","sequence":"first","affiliation":[{"name":"Department of Pathology Seth G.S. Medical College and King, Edward Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3354-2637","authenticated-orcid":false,"given":"Mona","family":"Agnihotri","sequence":"additional","affiliation":[{"name":"Department of Pathology Seth G.S. Medical College and King, Edward Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kanchan","family":"Kothari","sequence":"additional","affiliation":[{"name":"Department of Pathology Seth G.S. Medical College and King, Edward Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aditi","family":"Raj","sequence":"additional","affiliation":[{"name":"Department of Pathology Seth G.S. Medical College and King, Edward Memorial Hospital Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,25]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"280","DOI":"10.4103\/amhsr.amhsr_339_14","article-title":"Adnexal Tumors of Skin: An Experience at a Tertiary Care Centre at Delhi","volume":"6","author":"Pujani M.","year":"2016","journal-title":"Annals of Medical and Health Sciences Research"},{"key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"562","DOI":"10.7861\/clinmedicine.17-6-562","article-title":"Inherited Skin Tumour Syndromes","volume":"17","author":"Brown S.","year":"2017","journal-title":"Clinical Medicine"},{"key":"e_1_2_10_4_1","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1159\/000447733","article-title":"Diagnostic Evaluation of Skin Adnexal Tumors by Fine\u2010Needle Aspiration Cytology","volume":"60","author":"Chand P.","year":"2016","journal-title":"Acta Cytologica"},{"key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1002\/dc.23741","article-title":"Fine\u2010Needle Aspiration Cytology in Primary Cutaneous Tumors","volume":"45","author":"Bharani V.","year":"2017","journal-title":"Diagnostic Cytopathology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"37","DOI":"10.25259\/Cytojournal_19_2023","article-title":"Cytomorphology of Skin Adnexal Tumors and Its Correlation With Histopathology in a Tertiary Care Center","volume":"20","author":"Shahab J.","year":"2023","journal-title":"CytoJournal"},{"key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/cyt.70074","article-title":"Cytomorphological Features of Scalp Cylindroma: Insights From Fine Needle Aspiration Cytology","volume":"37","author":"Saraf P.","year":"2026","journal-title":"Cytopathology"},{"key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1002\/dc.10161","article-title":"Pilomatrixoma: Clinicopathologic Study of 51 Cases With Emphasis on Cytologic Features","volume":"27","author":"Wang J.","year":"2002","journal-title":"Diagnostic Cytopathology"},{"key":"e_1_2_10_9_1","doi-asserted-by":"crossref","first-page":"30","DOI":"10.4103\/1742-6413.144689","article-title":"Fine Needle Aspiration Cytology of Pilomatrixoma: A Short Series of Three Cases","volume":"11","author":"Nigam J. S.","year":"2014","journal-title":"CytoJournal"},{"key":"e_1_2_10_10_1","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1159\/000325801","article-title":"Pilomatrixoma as a Diagnostic Pitfall in Fine Needle Aspiration Cytology: A Case Report","volume":"51","author":"Sivakumar S.","year":"2007","journal-title":"Acta Cytologica"},{"key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"45","DOI":"10.4132\/jptm.2017.10.18","article-title":"Importance of Individual Ghost Cells in Fine\u2010Needle Aspiration Cytology Diagnosis of Pilomatricoma","volume":"52","author":"Han K.","year":"2018","journal-title":"Journal of Pathology and Translational Medicine"},{"key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"130","DOI":"10.4103\/0974-2727.141519","article-title":"Fine Needle Aspiration Cytology of Eccrine Spiradenoma of Back: Report of a Rare Case","volume":"6","author":"Sinha A.","year":"2014","journal-title":"Journal of Laboratory Physicians"},{"key":"e_1_2_10_13_1","doi-asserted-by":"crossref","first-page":"852","DOI":"10.1159\/000332716","article-title":"Eccrine Spiradenoma Mimicking Adenoid Cystic Carcinoma on Fine Needle Aspiration. A Case Report","volume":"41","author":"Kolda T. F.","year":"1997","journal-title":"Acta Cytologica"},{"key":"e_1_2_10_14_1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.4103\/0970-9371.197616","article-title":"Cytopathologic Features of an Unusual Case of Multiple Eccrine Spiradenomas Misdiagnosed as a Malignant Round Cell Tumor","volume":"34","author":"Rekhi B.","year":"2017","journal-title":"Journal of Cytology"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.70131","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.70131","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.70131","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T14:56:23Z","timestamp":1790348183000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.70131"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,25]]},"references-count":13,"alternative-id":["10.1111\/cyt.70131"],"URL":"https:\/\/doi.org\/10.1111\/cyt.70131","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,25]]},"assertion":[{"value":"2025-09-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cyt.70131"}}