{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:58:10Z","timestamp":1790413090069,"version":"4.1.0"},"reference-count":11,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T00:00:00Z","timestamp":1790380800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cytopathology"],"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Giant cell tumour of bone (GCTB) is a locally aggressive primary bone neoplasm that predominantly involves the epiphyseal\u2010metaphyseal regions of long bones. Involvement of the mobile spine is uncommon, with cervical vertebral localization being particularly rare. Preoperative diagnosis at this site can be challenging because of overlapping clinical, radiologic and morphologic features with other giant cell\u2010rich lesions.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Case<\/jats:title>\n                    <jats:p>A 60\u2010year\u2010old woman presented with progressive neck pain, upper\u2010limb paresthesias and a posterior cervical swelling. Imaging revealed an expansile osteolytic lesion involving the C2\u2013C4 vertebrae, with cortical destruction and soft tissue extension. CT\u2010guided fine\u2010needle aspiration cytology (FNAC) revealed highly cellular smears composed of bland mononuclear stromal cells intimately admixed with numerous uniformly distributed osteoclast\u2010type multinucleated giant cells. The striking similarity between the nuclei of the giant cells and mononuclear stromal cells provided an important diagnostic clue. In the absence of significant cytologic atypia, atypical mitoses, malignant osteoid or necrosis, a cytologic diagnosis of GCTB was rendered. Subsequent histopathologic examination of the resection specimen confirmed the diagnosis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>GCTB should be considered in the differential diagnosis of giant cell\u2010rich osteolytic vertebral lesions, despite its rarity at this site. Recognition of characteristic cytomorphologic features, particularly the uniform distribution of osteoclast\u2010type giant cells and their nuclear similarity to mononuclear stromal cells, together with clinicoradiologic correlation, can enable accurate preoperative diagnosis on image\u2010guided FNAC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/cyt.70135","type":"journal-article","created":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:01:50Z","timestamp":1790409710000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A Giant in the Neck: Cytomorphology of a Rare Cervical Vertebral Lesion"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2069-0654","authenticated-orcid":false,"given":"Nisha","family":"Duggal","sequence":"first","affiliation":[{"name":"Department of Cytology and Gynecological Pathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-5490-4619","authenticated-orcid":false,"given":"Vivek Premshankar","family":"Tiwari","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0734-3252","authenticated-orcid":false,"given":"Chirag","family":"Ahuja","sequence":"additional","affiliation":[{"name":"Department of Radiodiagnosis and Imaging Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7006-5147","authenticated-orcid":false,"given":"Uma Nahar","family":"Saikia","sequence":"additional","affiliation":[{"name":"Department of Histopathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2159-4325","authenticated-orcid":false,"given":"Parikshaa","family":"Gupta","sequence":"additional","affiliation":[{"name":"Department of Cytology and Gynecological Pathology Postgraduate Institute of Medical Education and Research  Chandigarh India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,9,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1007\/s00264-006-0215-7","article-title":"Giant Cell Tumor of Bone: Morphological, Biological and Histogenetical Aspects","volume":"30","author":"Werner M.","year":"2006","journal-title":"International Orthopaedics"},{"issue":"9","key":"e_1_2_10_3_1","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1007\/s11547-013-0352-1","article-title":"Giant Cell Tumours of the Mobile Spine: Characteristic Imaging Features and Differential Diagnosis","volume":"119","author":"Si M. J.","year":"2014","journal-title":"La Radiologia Medica"},{"key":"e_1_2_10_4_1","volume-title":"Giant Cell Tumor of Bone and Other Giant Cell\u2010Rich Lesions. Monographs in Clinical Cytology","author":"Domanski H.","year":"2017"},{"issue":"2","key":"e_1_2_10_5_1","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1111\/cyt.12928","article-title":"Cytological Diagnosis of Osteosarcoma With Emphasis on Diagnostic Pitfalls","volume":"32","author":"Gupta P.","year":"2021","journal-title":"Cytopathology"},{"key":"e_1_2_10_6_1","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1002\/dc.20974","article-title":"Fine\u2010Needle Aspiration of Brown Tumor of Bone: Cytologic Features With Radiologic and Histologic Correlation","volume":"37","author":"Pavlovic S.","year":"2009","journal-title":"Diagnostic Cytopathology"},{"issue":"7","key":"e_1_2_10_7_1","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1002\/dc.22998","article-title":"Giant Cell Tumor of Bone Presenting in the Lumbar Spine of a 35\u2010Year\u2010Old Female: Cytodiagnosis and Other Diagnostic Considerations","volume":"42","author":"Witt B. L.","year":"2014","journal-title":"Diagnostic Cytopathology"},{"issue":"8","key":"e_1_2_10_8_1","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1002\/cncy.22000","article-title":"Immunohistochemistry for Histone H3G34W and H3K36M Is Highly Specific for Giant Cell Tumor of Bone and Chondroblastoma, Respectively, in FNA and Core Needle Biopsy","volume":"126","author":"Schaefer I. M.","year":"2018","journal-title":"Cancer Cytopathology"},{"issue":"5","key":"e_1_2_10_9_1","first-page":"590","article-title":"Validation of Fluorescence In\u00a0Situ Hybridization Testing of USP6 Gene Rearrangement for Diagnosis of Primary Aneurysmal Bone Cyst","volume":"49","author":"Li L.","year":"2019","journal-title":"Annals of Clinical and Laboratory Science"},{"issue":"1","key":"e_1_2_10_10_1","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-04530-z","article-title":"Recurrent Rearrangements of FOS and FOSB Define Osteoblastoma","volume":"9","author":"Fittall M. W.","year":"2018","journal-title":"Nature Communications"},{"issue":"11","key":"e_1_2_10_11_1","doi-asserted-by":"crossref","first-page":"1577","DOI":"10.1097\/PAS.0000000000001963","article-title":"Brown Tumors Belong to the Spectrum of KRAS\u2010Driven Neoplasms","volume":"46","author":"Turek D.","year":"2022","journal-title":"American Journal of Surgical Pathology"},{"issue":"2","key":"e_1_2_10_12_1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cjp2.13","article-title":"Diagnostic Value of H3F3A Mutations in Giant Cell Tumour of Bone Compared to Osteoclast\u2010Rich Mimics","volume":"1","author":"Presneau N.","year":"2015","journal-title":"Journal of Pathology. Clinical Research"}],"container-title":["Cytopathology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.70135","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/cyt.70135","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/cyt.70135","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,26]],"date-time":"2026-09-26T08:01:53Z","timestamp":1790409713000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/cyt.70135"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,9,26]]},"references-count":11,"alternative-id":["10.1111\/cyt.70135"],"URL":"https:\/\/doi.org\/10.1111\/cyt.70135","archive":["Portico"],"relation":{},"ISSN":["0956-5507","1365-2303"],"issn-type":[{"value":"0956-5507","type":"print"},{"value":"1365-2303","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,9,26]]},"assertion":[{"value":"2026-07-28","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-09-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"cyt.70135"}}